Assessment of Structural Intolerance and Durability
General Structure Information 2xvs TTC5 crystal structure of human ttc5 (strap) c-terminal ob domain 1.8Å AUTH C.J.ADAMS,A.C.PIKE,S.MANIAM,T.D.SHARPE,A.S.COUTTS,S.KNAPP,AUTH 2 N.B.LA THANGUE,A.N.BULLOCKTITL THE P53 COFACTOR STRAP EXHIBITS AN UNEXPECTED TPR MOTIF ANDTITL 2 OLIGONUCLEOTIDE-BINDING (OB)-FOLD STRUCTURE.REF PROC.NATL.ACAD.SCI.USA V. 109 3778 2012REFN ISSN 0027-8424PMID 22362889DOI 10.1073/PNAS.1113731109 Variant Set Distributions Mapped Variants
General Structure Information 4gll UXS1 crystal structure of human udp-xylose synthase. 2.5Å AUTH S.J.POLIZZI,R.M.WALSH,W.B.PEEPLES,J.M.LIM,L.WELLS,Z.A.WOODTITL HUMAN UDP-ALPHA-D-XYLOSE SYNTHASE AND ESCHERICHIA COLI ARNATITL 2 CONSERVE A CONFORMATIONAL SHUNT THAT CONTROLS WHETHER XYLOSETITL 3 OR 4-KETO-XYLOSE IS PRODUCED.REF BIOCHEMISTRY V. 51 8844 2012REFN ISSN 0006-2960PMID 23072385DOI 10.1021/BI301135B Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3rq4 SUV420H2 crystal structure of suppressor of variegation 4-20 homolog 2 1.8Å AUTH H.WU,A.SIARHEYEVA,H.ZENG,R.LAM,A.DONG,X.H.WU,Y.LI,AUTH 2 M.SCHAPIRA,M.VEDADI,J.MINTITL CRYSTAL STRUCTURES OF THE HUMAN HISTONE H4K20TITL 2 METHYLTRANSFERASES SUV420H1 AND SUV420H2.REF FEBS LETT. V. 587 3859 2013REFN ISSN 0014-5793PMID 24396869 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2em3 ZFP28 solution structure of the c2h2 type zinc finger (region 640- 672) of human zinc finger protein 28 homolog -1.0Å AUTH N.TOCHIO,T.TOMIZAWA,H.ABE,K.SAITO,H.LI,M.SATO,AUTH 2 S.KOSHIBA,N.KOBAYASHI,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGERTITL 2 (REGION 640-672) OF HUMAN ZINC FINGER PROTEIN 28TITL 3 HOMOLOGREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3dh1 ADAT2 crystal structure of human trna-specific adenosine-34 deaminase subunit adat2 2.8Å AUTH M.WELIN,L.TRESAUGUES,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,S.FLODIN,A.FLORES,AUTH 3 S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,L.LEHTIO,M.MOCHE,M.E.NILSSON,T.NYMAN,K.OLESEN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,S.VAN DER BERG,AUTH 6 M.WISNIEWSKA,M.WIKSTROM,P.NORDLUNDTITL CRYSTAL STRUCTURE OF HUMAN TRNA-SPECIFIC ADENOSINE-34TITL 2 DEAMINASE SUBUNIT ADAT2.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3og4 IFNLR1 the crystal structure of human interferon lambda 1 complexed with its high affinity receptor in space group p21212 2.16Å AUTH Z.J.MIKNIS,E.MAGRACHEVA,W.LI,A.ZDANOV,S.V.KOTENKO,A.WLODAWERTITL CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN INTERFERON-LAMBDA1TITL 2 WITH ITS HIGH AFFINITY RECEPTOR INTERFERON-LAMBDAR1.REF J.MOL.BIOL. V. 404 650 2010REFN ISSN 0022-2836PMID 20934432DOI 10.1016/J.JMB.2010.09.068 Variant Set Distributions Ripley’s K […]
General Structure Information 4i7c SIAH1 siah1 mutant bound to synthetic peptide (ace)klrpv(23p)mvrpwvr 2.8Å AUTH J.L.STEBBINS,E.SANTELLI,Y.FENG,S.K.DE,A.PURVES,AUTH 2 K.MOTAMEDCHABOKI,B.WU,Z.A.RONAI,R.C.LIDDINGTON,M.PELLECCHIATITL STRUCTURE-BASED DESIGN OF COVALENT SIAH INHIBITORS.REF CHEM.BIOL. V. 20 973 2013REFN ISSN 1074-5521PMID 23891150DOI 10.1016/J.CHEMBIOL.2013.06.008 Variant Set Distributions Mapped Variants
General Structure Information 2qgx UBE2Q1 ubiquitin-conjugating enzyme e2q 2.56Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Mapped Variants
General Structure Information 4nn2 PHF6 protein crystal structure of human borjeson-forssman-lehmann syndrome associated protein phf6 1.47Å AUTH Z.LIU,F.LI,J.ZHANG,Y.MEI,J.WU,Y.SHITITL CRYSTAL STRUCTURE OF THE SECOND EXTENDED PHD DOMAIN OF HUMANTITL 2 PHF6 PROTEINREF J.BIOL.CHEM. 2014REFN ESSN 1083-351X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2m38 ANKS1B ptb domain of aida1 -1.0Å AUTH L.DONALDSONTITL TO BE PUBLISHEDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants