Assessment of Structural Intolerance and Durability
General Structure Information 1eaz PLEKHA1 crystal structure of the phosphoinositol (3,4)-bisphosphate binding ph domain of tapp1 from human. 1.4Å AUTH C.C.THOMAS,S.DOWLER,M.DEAK,D.R.ALESSI,AUTH 2 D.M.F.VAN AALTENTITL CRYSTAL STRUCTURE OF THE PHOSPHATIDYLINOSITOLTITL 2 3,4-BISPHOSPHATE-BINDING PLECKSTRIN HOMOLOGY (PH)TITL 3 DOMAIN OF TANDEM PH-DOMAIN-CONTAINING PROTEIN 1TITL 4 (TAPP1): MOLECULAR BASIS OF LIPID SPECIFICITYREF BIOCHEM.J. V. 358 287 2001REFN ISSN 0264-6021PMID […]
General Structure Information 2mgx SRA1 nmr structure of sra1p c-terminal domain -1.0Å AUTH S.M.BILINOVICH,C.M.DAVIS,D.L.MORRIS,L.A.RAY,J.W.PROKOP,AUTH 2 G.J.BUCHAN,T.C.LEEPERTITL THE C-TERMINAL DOMAIN OF SRA1P HAS A FOLD MORE SIMILAR TOTITL 2 PRP18 THAN TO AN RRM AND DOES NOT DIRECTLY BIND TO THE SRA1TITL 3 RNA STR7 REGION.REF J.MOL.BIOL. V. 426 1753 2014REFN ISSN 0022-2836PMID 24486611DOI 10.1016/J.JMB.2014.01.007 Variant […]
General Structure Information 3zi1 GLOD4 crystal structure of human glyoxalase domain-containing protein 4 (glod4) 1.9Å AUTH A.OBERHOLZE,W.KIYANI,L.SHRESTHA,M.VOLLMAR,T.KROJER,AUTH 2 D.S.FROESE,E.WILLIAMS,F.VON DELFT,N.BURGESS-BROWN,AUTH 3 C.H.ARROWSMITH,A.EDWARDS,C.BOUNTRA,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN GLYOXALASE DOMAIN- CONTAININGTITL 2 PROTEIN 4 (GLOD4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4e74 PLXNA4 crystal structure of the rho gtpase binding domain of plexin a4a 1.58Å AUTH X.GUAN,H.WANG,W.TEMPEL,A.DONG,Y.TONG,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,H.PARKTITL CRYSTAL STRUCTURE OF THE RHO GTPASE BINDING DOMAIN OF PLEXINTITL 2 A4AREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ceg BIRC6 crystal structure of the ubc domain of baculoviral iap repeat- containing protein 6 2.01Å AUTH Y.SHENG,J.H.HONG,R.DOHERTY,T.SRIKUMAR,J.SHLOUSH,AUTH 2 G.V.AVVAKUMOV,J.R.WALKER,S.XUE,D.NECULAI,J.W.WAN,S.K.KIM,AUTH 3 C.H.ARROWSMITH,B.RAUGHT,S.DHE-PAGANONTITL A HUMAN UBIQUITIN CONJUGATING ENZYME (E2)-HECT E3 LIGASETITL 2 STRUCTURE-FUNCTION SCREEN.REF MOL CELL PROTEOMICS V. 11 329 2012REFNPMID 22496338DOI 10.1074/MCP.O111.013706 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3o65 ATXN3L crystal structure of a josephin-ubiquitin complex: evolutionary restraints on ataxin-3 deubiquitinating activity 2.7Å AUTH S.D.WEEKS,K.C.GRASTY,L.HERNANDEZ-CUEBAS,P.J.LOLLTITL CRYSTAL STRUCTURE OF A JOSEPHIN-UBIQUITIN COMPLEX:TITL 2 EVOLUTIONARY RESTRAINTS ON ATAXIN-3 DEUBIQUITINATINGTITL 3 ACTIVITY.REF J.BIOL.CHEM. V. 286 4555 2011REFN ISSN 0021-9258PMID 21118805DOI 10.1074/JBC.M110.177360 Variant Set Distributions Mapped Variants
General Structure Information 3rau PTPN23 crystal structure of the hd-ptp bro1 domain 1.95Å AUTH P.SETTE,R.MU,V.DUSSUPT,J.JIANG,G.SNYDER,P.SMITH,T.S.XIAO,AUTH 2 F.BOUAMRTITL THE PHE105 LOOP OF ALIX BRO1 DOMAIN PLAYS A KEY ROLE INTITL 2 HIV-1 RELEASE.REF STRUCTURE V. 19 1485 2011REFN ISSN 0969-2126PMID 21889351DOI 10.1016/J.STR.2011.07.016 Variant Set Distributions Mapped Variants
General Structure Information 1whl CYLD solution structure of the 1st cap-gly domain in human cylindromatosis tumor suppressor cyld -1.0Å AUTH K.SAITO,S.KOSHIBA,M.INOUE,T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 1ST CAP-GLY DOMAIN INTITL 2 HUMAN CYLINDROMATOSIS TUMOR SUPPRESSOR CYLDREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ega PELI2 crystal structure of pellino2 fha domain at 1.8 angstroms resolution 1.8Å AUTH C.C.LIN,Y.S.HUOH,K.R.SCHMITZ,L.E.JENSEN,K.M.FERGUSONTITL PELLINO PROTEINS CONTAIN A CRYPTIC FHA DOMAIN THAT MEDIATESTITL 2 INTERACTION WITH PHOSPHORYLATED IRAK1.REF STRUCTURE V. 16 1806 2008REFN ISSN 0969-2126PMID 19081057DOI 10.1016/J.STR.2008.09.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1ugk SYT4 solution structure of the first c2 domain of synaptotagmin iv from human fetal brain (kiaa1342) -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,M.SHIROUZU,T.TERADA,T.KIGAWA,AUTH 2 M.INOUE,T.YABUKI,M.AOKI,E.SEKI,T.MATSUDA,H.HIROTA,AUTH 3 M.YOSHIDA,A.TANAKA,T.OSANAI,Y.MATSUO,O.OHARA,AUTH 4 T.NAGASE,R.KIKUNO,M.NAKAYAMA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OFTITL 2 SYNAPTOTAGMIN IV FROM HUMAN FETAL BRAIN (KIAA1342)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants