Assessment of Structural Intolerance and Durability
General Structure Information 2ocb RAB9B crystal structure of human rab9b in complex with a gtp analogue 2.2Å AUTH B.HONG,L.SHEN,J.R.WALKER,W.TEMPEL,R.LANDRY,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAB9B IN COMPLEX WITH ATITL 2 GTP ANALOGUEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4b86 MSL2 crystal structure of the msl1-msl2 complex (3.5a) 3.5Å AUTH E.HALLACLI,M.LIPP,P.GEORGIEV,C.SPIELMAN,S.CUSACK,A.AKHTAR,AUTH 2 J.KADLECTITL MSL1-MEDIATED DIMERIZATION OF THE DOSAGE COMPENSATIONTITL 2 COMPLEX IS ESSENTIAL FOR MALE X-CHROMOSOME REGULATION INTITL 3 DROSOPHILA.REF MOL.CELL V. 48 587 2012REFN ISSN 1097-2765PMID 23084835DOI 10.1016/J.MOLCEL.2012.09.014 Variant Set Distributions Mapped Variants
General Structure Information 1jlj GPHN 1.6 angstrom crystal structure of the human neuroreceptor anchoring and molybdenum cofactor biosynthesis protein gephyrin 1.6Å AUTH G.SCHWARZ,N.SCHRADER,R.R.MENDEL,H.J.HECHT,AUTH 2 H.SCHINDELINTITL CRYSTAL STRUCTURES OF HUMAN GEPHYRIN AND PLANTTITL 2 CNX1 G DOMAINS: COMPARATIVE ANALYSIS ANDTITL 3 FUNCTIONAL IMPLICATIONS.REF J.MOL.BIOL. V. 312 405 2001REFN ISSN 0022-2836PMID 11554796DOI 10.1006/JMBI.2001.4952 Variant Set Distributions Ripley’s […]
General Structure Information 2jbh PRTFDC1 human phosphoribosyl transferase domain containing 1 1.7Å AUTH M.WELIN,L.EGEBLAD,A.JOHANSSON,P.STENMARK,L.WANG,S.FLODIN,AUTH 2 T.NYMAN,L.TRESAUGUES,T.KOTENYOVA,I.JOHANSSON,S.ERIKSSON,AUTH 3 H.EKLUND,P.NORDLUNDTITL STRUCTURAL AND FUNCTIONAL STUDIES OF THE HUMANTITL 2 PHOSPHORIBOSYLTRANSFERASE DOMAIN CONTAINING PROTEIN 1.REF FEBS J. V. 277 4920 2010REFN ISSN 1742-464XPMID 21054786DOI 10.1111/J.1742-4658.2010.07897.X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3i3n KLHL11 crystal structure of the btb-back domains of human klhl11 2.6Å AUTH J.W.MURRAY,C.D.O.COOPER,T.KROJER,P.MAHAJAN,E.SALAH,AUTH 2 T.KEATES,P.SAVITSKY,A.C.W.PIKE,A.ROOS,J.MUNIZ,AUTH 3 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,AUTH 4 A.EDWARDS,S.KNAPP,A.BULLOCK,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE BTB-BACK DOMAINS OF HUMANTITL 2 KLHL11REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gls SIRT3 crystal structure of human sirt3 2.7Å AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928 Variant Set Distributions Mapped Variants
General Structure Information 2edj ROBO2 solution structure of the fifth ig-like domain from human roundabout homolog 2 -1.0Å AUTH C.KUROSAKI,K.IZUMI,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIFTH IG-LIKE DOMAINTITL 2 FROM HUMAN ROUNDABOUT HOMOLOG 2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2q4k C11orf68 ensemble refinement of the protein crystal structure of gene product from homo sapiens hs.433573 2.5Å AUTH E.J.LEVIN,D.A.KONDRASHOV,G.E.WESENBERG,G.N.PHILLIPSTITL ENSEMBLE REFINEMENT OF PROTEIN CRYSTAL STRUCTURES:TITL 2 VALIDATION AND APPLICATION.REF STRUCTURE V. 15 1040 2007REFN ISSN 0969-2126PMID 17850744DOI 10.1016/J.STR.2007.06.019 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3zyi LRRC4 netring2 in complex with ngl2 2.6Å AUTH E.SEIRADAKE,C.H.COLES,P.V.PERESTENKO,K.HARLOS,AUTH 2 R.A.J.MCILHINNEY,A.R.ARICESCU,E.Y.JONESTITL STRUCTURAL BASIS FOR CELL SURFACE PATTERNING THROUGHTITL 2 NETRING-NGL INTERACTIONSREF EMBO J. V. 30 4479 2011REFN ISSN 0261-4189PMID 21946559DOI 10.1038/EMBOJ.2011.346 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4fom PVRL3 crystal structure of human nectin-3 full ectodomain (d1-d3) 3.93Å AUTH O.J.HARRISON,J.VENDOME,J.BRASCH,X.JIN,S.HONG,P.S.KATSAMBA,AUTH 2 G.AHLSEN,R.B.TROYANOVSKY,S.M.TROYANOVSKY,B.HONIG,L.SHAPIROTITL NECTIN ECTODOMAIN STRUCTURES REVEAL A CANONICAL ADHESIVETITL 2 INTERFACE.REF NAT.STRUCT.MOL.BIOL. V. 19 906 2012REFN ISSN 1545-9993PMID 22902367DOI 10.1038/NSMB.2366 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants