Assessment of Structural Intolerance and Durability
General Structure Information 1xqr HSPBP1 crystal structure of the hspbp1 core domain 2.1Å AUTH Y.SHOMURA,Z.DRAGOVIC,H.C.CHANG,N.TZVETKOV,AUTH 2 J.C.YOUNG,J.L.BRODSKY,V.GUERRIERO,F.U.HARTL,AUTH 3 A.BRACHERTITL REGULATION OF HSP70 FUNCTION BY HSPBP1; STRUCTURALTITL 2 ANALYSIS REVEALS AN ALTERNATE MECHANISM FOR HSP70TITL 3 NUCLEOTIDE EXCHANGEREF MOL.CELL V. 17 367 2005REFN ISSN 1097-2765PMID 15694338DOI 10.1016/J.MOLCEL.2004.12.023 Variant Set Distributions Mapped Variants
General Structure Information 2dmh MYOF solution structure of the first c2 domain of human myoferlin -1.0Å AUTH T.NAGASHIMA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE FIRST C2 DOMAIN OF HUMANTITL 2 MYOFERLINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nwm GGA1 gat domain of human gga1 2.4Å AUTH S.SUER,S.MISRA,L.F.SAIDI,J.H.HURLEYTITL STRUCTURE OF THE GAT DOMAIN OF HUMAN GGA1: ATITL 2 SYNTAXIN AMINO-TERMINAL DOMAIN FOLD IN ANTITL 3 ENDOSOMAL TRAFFICKING ADAPTOR.REF PROC.NATL.ACAD.SCI.USA V. 100 4451 2003REFN ISSN 0027-8424PMID 12668765DOI 10.1073/PNAS.0831133100 Variant Set Distributions Mapped Variants
General Structure Information 3fn3 CD274 dimeric structure of pd-l1 2.7Å AUTH Y.CHEN,P.LIU,F.GAO,H.CHENG,J.QI,G.F.GAOTITL A DIMERIC STRUCTURE OF PD-L1: FUNCTIONAL UNITS ORTITL 2 EVOLUTIONARY RELICS?REF PROTEIN CELL V. 1 153 2010REFN ISSN 1674-800XPMID 21203985DOI 10.1007/S13238-010-0022-1 Variant Set Distributions Mapped Variants
General Structure Information 3sop SEPT3 crystal structure of human septin 3 gtpase domain 2.88Å AUTH J.N.MACEDO,N.F.VALADARES,I.A.MARQUES,F.M.FERREIRA,AUTH 2 J.C.DAMALIO,H.M.PEREIRA,R.C.GARRATT,A.P.ARAUJOTITL THE STRUCTURE AND PROPERTIES OF SEPTIN 3: A POSSIBLE MISSINGTITL 2 LINK IN SEPTIN FILAMENT FORMATION.REF BIOCHEM.J. V. 450 95 2013REFN ISSN 0264-6021PMID 23163726DOI 10.1042/BJ20120851 Variant Set Distributions Mapped Variants
General Structure Information 4bqm GLS2 crystal structure of human liver-type glutaminase, catalytic domain 2.18Å AUTH I.M.FERREIRA,M.VOLLMAR,T.KROJER,C.STRAIN-DAMERELL,S.FROESE,AUTH 2 D.COUTANDIN,E.WILLIAMS,N.BURGESS-BROWN,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,C.BOUNTRA,A.EDWARDS,S.M.G.DIAS,AUTH 4 A.L.B.AMBROSIO,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN LIVER-TYPE GLUTAMINASE,TITL 2 CATALYTIC DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2lfe HECW2 solution nmr structure of n-terminal domain of human e3 ubiquitin- protein ligase hecw2, northeast structural genomics consortium (nesg) target ht6306a -1.0Å AUTH A.LEMAK,A.YEE,S.HOULISTON,M.GARCIA,S.CHITAYAT,S.DHE-PAGANON,AUTH 2 G.T.MONTELIONE,C.ARROWSMITHTITL NMR SOLUTION STRUCTURE OF N-TERMINAL DOMAIN OF E3 LIGASETITL 2 HECW2REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4dyo DNPEP crystal structure of human aspartyl aminopeptidase (dnpep) in complex with aspartic acid hydroxamate 2.2Å AUTH A.CHAIKUAD,E.S.PILKA,A.D.RISO,F.V.DELFT,K.L.KAVANAGH,AUTH 2 C.VENIEN-BRYAN,U.OPPERMANN,W.W.YUETITL STRUCTURE OF HUMAN ASPARTYL AMINOPEPTIDASE COMPLEXED WITHTITL 2 SUBSTRATE ANALOGUE: INSIGHT INTO CATALYTIC MECHANISM,TITL 3 SUBSTRATE SPECIFICITY AND M18 PEPTIDASE FAMILY.REF BMC STRUCT.BIOL. V. 12 14 2012REFN ESSN 1472-6807PMID 22720794DOI 10.1186/1472-6807-12-14 Variant […]
General Structure Information 2kyx PPIE solution structure of the rrm domain of cyp33 -1.0Å AUTH S.PARK,U.OSMERS,G.RAMAN,R.H.SCHWANTES,M.O.DIAZ,AUTH 2 J.H.BUSHWELLERTITL THE PHD3 DOMAIN OF MLL ACTS AS A CYP33-REGULATED SWITCHTITL 2 BETWEEN MLL-MEDIATED ACTIVATION AND REPRESSION .REF BIOCHEMISTRY V. 49 6576 2010REFN ISSN 0006-2960PMID 20677832DOI 10.1021/BI1009387 Variant Set Distributions Mapped Variants
General Structure Information 2hak MARK1 catalytic and ubiqutin-associated domains of mark1/par-1 2.6Å AUTH A.MARX,C.NUGOOR,J.MUELLER,S.PANNEERSELVAM,T.TIMM,AUTH 2 M.BILANG,E.MYLONAS,D.I.SVERGUN,E.-M.MANDELKOW,AUTH 3 E.MANDELKOWTITL STRUCTURAL VARIATIONS IN THE CATALYTIC ANDTITL 2 UBIQUITIN-ASSOCIATED DOMAINS OFTITL 3 MICROTUBULE-ASSOCIATED PROTEIN/MICROTUBULETITL 4 AFFINITY REGULATING KINASE (MARK) 1 AND MARK2REF J.BIOL.CHEM. V. 281 27586 2006REFN ISSN 0021-9258PMID 16803889DOI 10.1074/JBC.M604865200 Variant Set Distributions Ripley’s K Analysis Plots […]