Assessment of Structural Intolerance and Durability
General Structure Information 3qxy SETD6 human setd6 in complex with rela lys310 2.09Å AUTH Y.CHANG,D.LEVY,J.R.HORTON,J.PENG,X.ZHANG,O.GOZANI,X.CHENGTITL STRUCTURAL BASIS OF SETD6-MEDIATED REGULATION OF THE NF-KBTITL 2 NETWORK VIA METHYL-LYSINE SIGNALING.REF NUCLEIC ACIDS RES. V. 39 6380 2011REFN ISSN 0305-1048PMID 21515635DOI 10.1093/NAR/GKR256 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3oes RHEBL1 crystal structure of the small gtpase rhebl1 2.3Å AUTH L.NEDYALKOVA,N.ZHONG,W.TEMPEL,Y.TONG,L.SHEN,P.LOPPNAU,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SMALL GTPASE RHEBL1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3qye TBC1D1 crystal structure of human tbc1d1 rabgap domain 2.2Å AUTH S.Y.PARK,W.JIN,J.R.WOO,S.E.SHOELSONTITL CRYSTAL STRUCTURES OF HUMAN TBC1D1 AND TBC1D4 (AS160)TITL 2 RABGTPASE-ACTIVATING PROTEIN (RABGAP) DOMAINS REVEALTITL 3 CRITICAL ELEMENTS FOR GLUT4 TRANSLOCATION.REF J.BIOL.CHEM. V. 286 18130 2011REFN ISSN 0021-9258PMID 21454505DOI 10.1074/JBC.M110.217323 Variant Set Distributions Mapped Variants
General Structure Information 3fkc ZBTB33 crystal structure of human zinc finger and btb domain containing 33 1.7Å AUTH P.FILIPPAKOPOULOS,A.BULLOCK,T.KEATES,N.BURGESS-BROWN,AUTH 2 J.MUNIZ,F.VON DELFT,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,AUTH 3 C.BOUNTRA,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN ZINC FINGER AND BTB DOMAINTITL 2 CONTAINING 33REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1mp1 SRRM1 solution structure of the pwi motif from srm160 -1.0Å AUTH B.R.SZYMCZYNA,J.BOWMAN,S.MCCRACKEN,A.PINEDA-LUCENA,AUTH 2 Y.LU,B.COX,M.LAMBERMON,B.R.GRAVELEY,C.H.ARROWSMITH,AUTH 3 B.J.BLENCOWETITL STRUCTURE AND FUNCTION OF THE PWI MOTIF: A NOVELTITL 2 NUCLEIC ACID-BINDING DOMAIN THAT FACILITATESTITL 3 PRE-MRNA PROCESSING.REF GENES DEV. V. 17 461 2003REFN ISSN 0890-9369PMID 12600940DOI 10.1101/GAD.1060403 Variant Set Distributions Mapped Variants
General Structure Information 2wek ZADH2 crystal structure of the human mgc45594 gene product in complex with diclofenac 1.9Å AUTH N.SHAFQAT,W.W.YUE,F.NIESEN,U.OPPERMANNTITL CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT INTITL 2 COMPLEX WITH DICLOFENACREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3un9 NLRX1 crystal structure of an immune receptor 2.65Å AUTH M.HONG,S.I.YOON,I.A.WILSONTITL STRUCTURE AND FUNCTIONAL CHARACTERIZATION OF THE RNA-BINDINGTITL 2 ELEMENT OF THE NLRX1 INNATE IMMUNE MODULATOR.REF IMMUNITY V. 36 337 2012REFN ISSN 1074-7613PMID 22386589DOI 10.1016/J.IMMUNI.2011.12.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2aft SUMF1 formylglycine generating enzyme c336s mutant 1.66Å AUTH D.ROESER,A.PREUSSER-KUNZE,B.SCHMIDT,K.GASOW,J.G.WITTMANN,AUTH 2 T.DIERKS,K.VON FIGURA,M.G.RUDOLPHTITL A GENERAL BINDING MECHANISM FOR ALL HUMAN SULFATASES BY THETITL 2 FORMYLGLYCINE-GENERATING ENZYMEREF PROC.NATL.ACAD.SCI.USA V. 103 81 2006REFN ISSN 0027-8424PMID 16368756DOI 10.1073/PNAS.0507592102 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4a35 ENOSF1 crystal structure of human mitochondrial enolase superfamily member 1 (enosf1) 1.74Å AUTH J.R.C.MUNIZ,D.S.FROESE,T.KROJER,M.VOLLMAR,P.CANNING,AUTH 2 U.OPPERMANN,C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,AUTH 3 F.VON DELFT,W.W.YUETITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ENOLASETITL 2 SUPERFAMILY MEMBER 1 (ENOSF1)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2v90 PDZD3 crystal structure of the 3rd pdz domain of intestine- and kidney-enriched pdz domain ikepp (pdzd3) 2.0Å AUTH J.UPPENBERG,C.GILEADI,C.PHILLIPS,J.ELKINS,G.BUNKOCZI,AUTH 2 C.COOPER,A.C.W.PIKE,E.SALAH,E.UGOCHUKWU,C.H.ARROWSMITH,AUTH 3 A.EDWARDS,M.SUNDSTROM,J.WEIGELT,D.A.DOYLETITL CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- ANDTITL 2 KIDNEY-ENRICHED PDZ DOMAIN IKEPP ( PDZD3)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants