General Structure Information
| PDB ID | 3f0w |
| HGNC Gene Label(s) | NUMBL |
| Structure Name | human numb-like protein, phosphotyrosine interaction domain |
| Resolution | 2.7Å |
| Reference | AUTH L.LEHTIO,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,H.BERGLUND,AUTH 2 C.BOUNTRA,R.D BUSAM,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,A.JOHANSSON,AUTH 4 I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,M.E.NILSSON,T.NYMAN,AUTH 5 C.PERSSON,J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 6 S.VAN DEN BERG,J.WEIGELT,M.WELIN,M.WIKSTROM,M.WISNIEWSKA,AUTH 7 P.NORDLUNDTITL HUMAN NUMB-LIKE PROTEIN, PHOSPHOTYROSINE INTERACTION DOMAINREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 141 |
| Number Of SNVs | 22 |
| Number Of Permutations | 2144 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.126 |
| p-value | 0.006 |
COSMIC
| Number Of Residues | 141 |
| Number Of SNVs | 4 |
| Number Of Permutations | 111 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.486 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 22 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.801 |
| p-value | 0.048 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
