General Structure Information
| PDB ID | 3e0l |
| HGNC Gene Label(s) | GDA |
| Structure Name | computationally designed ammelide deaminase |
| Resolution | 2.37Å |
| Reference | AUTH P.M.MURPHY,J.M.BOLDUC,J.L.GALLAHER,B.L.STODDARD,AUTH 2 D.BAKERTITL ALTERATION OF ENZYME SPECIFICITY BY COMPUTATIONALTITL 2 LOOP REMODELING AND DESIGN.REF PROC.NATL.ACAD.SCI.USA V. 106 9215 2009REFN ISSN 0027-8424PMID 19470646DOI 10.1073/PNAS.0811070106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 442 |
| Number Of SNVs | 94 |
| Number Of Permutations | 18214 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.294 |
| p-value | 0.467 |
COSMIC
| Number Of Residues | 442 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1528 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.071 |
| p-value | 0.724 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 94 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.089 |
| p-value | 1.0 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
