General Structure Information
| PDB ID | 3a1b |
| HGNC Gene Label(s) | DNMT3A |
| Structure Name | crystal structure of the dnmt3a add domain in complex with histone h3 |
| Resolution | 2.29Å |
| Reference | AUTH J.OTANI,T.NANKUMO,K.ARITA,S.INAMOTO,M.ARIYOSHI,M.SHIRAKAWATITL STRUCTURAL BASIS FOR RECOGNITION OF H3K4 METHYLATION STATUSTITL 2 BY THE DNA METHYLTRANSFERASE 3A ATRX-DNMT3-DNMT3L DOMAINREF EMBO REP. V. 10 1235 2009REFN ISSN 1469-221XPMID 19834512DOI 10.1038/EMBOR.2009.218 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 135 |
| Number Of SNVs | 18 |
| Number Of Permutations | 4799 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.026 |
| p-value | 0.63 |
COSMIC
| Number Of Residues | 135 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3222 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.071 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.275 |
| p-value | 0.675 |