General Structure Information
| PDB ID | 3qe9 |
| HGNC Gene Label(s) | EXO1 |
| Structure Name | crystal structure of human exonuclease 1 exo1 (d173a) in complex with dna (complex i) |
| Resolution | 2.51Å |
| Reference | AUTH J.ORANS,E.A.MCSWEENEY,R.R.IYER,M.A.HAST,H.W.HELLINGA,AUTH 2 P.MODRICH,L.S.BEESETITL STRUCTURES OF HUMAN EXONUCLEASE 1 DNA COMPLEXES SUGGEST ATITL 2 UNIFIED MECHANISM FOR NUCLEASE FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 212 2011REFN ISSN 0092-8674PMID 21496642DOI 10.1016/J.CELL.2011.03.005 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 345 |
| Number Of SNVs | 103 |
| Number Of Permutations | 48272 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.015 |
| p-value | 0.374 |
COSMIC
| Number Of Residues | 345 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.333 |
| p-value | 0.972 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 103 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | -0.322 |
| p-value | 0.777 |