General Structure Information
| PDB ID | 4i5l |
| HGNC Gene Label(s) | PPP2R3B |
| Structure Name | structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation |
| Resolution | 2.43Å |
| Reference | AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 355 |
| Number Of SNVs | 123 |
| Number Of Permutations | 33664 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.052 |
| p-value | 0.063 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| X:322278 | S>R | B:124 | (65.62, 89.39, 112.93) | |
| X:322273 | COSM1241612 | P>L | B:126 | (63.06, 85.05, 115.98) |
| X:322268 | F>L | B:128 | (64.56, 78.36, 115.74) | |
| X:322249 | R>H | B:134 | (55.90, 77.66, 119.06) | |
| X:322250 | COSM3694238 COSM3694237 |
R>C | B:134 | (55.90, 77.66, 119.06) |
| X:322246 | P>L | B:135 | (51.23, 76.87, 121.35) | |
| X:322235 | V>I | B:139 | (44.62, 77.20, 126.64) | |
| X:322226 | D>N | B:142 | (41.50, 77.80, 134.91) | |
| X:322220 | COSM4109050 COSM4109049 |
V>I | B:144 | (39.12, 72.71, 131.57) |
| X:322214 | rs186068809 | S>G | B:146 | (35.70, 74.30, 136.12) |
| X:322205 | E>K | B:149 | (36.23, 71.09, 139.61) | |
| X:322201 | S>N | B:150 | (31.32, 70.21, 137.75) | |
| X:322199 | T>A | B:151 | (31.85, 66.60, 136.10) | |
| X:322193 | rs149868172 | A>T | B:153 | (30.14, 66.96, 141.57) |
| X:322190 | R>W | B:154 | (27.24, 65.19, 137.56) | |
| X:322174 | R>T | B:159 | (36.88, 59.08, 144.38) | |
| X:322164 | M>I | B:162 | (36.31, 53.56, 133.98) | |
| X:322160 | D>N | B:164 | (32.21, 57.87, 135.86) | |
| X:322145 | A>T | B:169 | (36.61, 62.84, 128.62) | |
| X:308400 | G>E | B:180 | (41.64, 55.11, 129.93) | |
| X:308389 | Y>H | B:184 | (47.12, 53.72, 133.81) | |
| X:308380 | G>S | B:187 | (45.52, 56.12, 139.19) | |
| X:308367 | T>R | B:191 | (41.55, 51.88, 144.12) | |
| X:308355 | S>F | B:195 | (40.28, 62.15, 143.21) | |
| X:308353 | V>I | B:196 | (38.74, 65.87, 141.87) | |
| X:308350 | H>Y | B:197 | (43.49, 67.03, 144.20) | |
| X:308338 | A>S | B:201 | (46.70, 67.55, 138.88) | |
| X:308335 | M>L | B:202 | (46.82, 64.62, 135.36) | |
| X:308053 | H>Q | B:211 | (51.25, 72.83, 123.78) | |
| X:308047 | D>E | B:213 | (46.03, 65.80, 120.55) | |
| X:308049 | D>N | B:213 | (46.03, 65.80, 120.55) | |
| X:308046 | A>T | B:214 | (50.30, 63.85, 120.39) | |
| X:308042 | A>V | B:215 | (51.66, 65.29, 123.36) | |
| X:308034 | V>I | B:218 | (52.79, 60.51, 124.77) | |
| X:308018 | S>T | B:223 | (57.28, 56.43, 131.44) | |
| X:308015 | P>L | B:224 | (58.26, 58.95, 133.92) | |
| X:308013 | G>S | B:225 | (60.68, 61.30, 130.97) | |
| X:308006 | N>S | B:227 | (59.04, 62.31, 125.93) | |
| X:307998 | V>M | B:230 | (56.93, 51.27, 124.69) | |
| X:307992 | E>K | B:232 | (54.68, 47.46, 126.95) | |
| X:307986 | F>L | B:234 | (49.94, 51.72, 123.25) | |
| X:307983 | V>I | B:235 | (48.01, 47.58, 127.42) | |
| X:307973 | L>S | B:238 | (43.93, 48.20, 123.56) | |
| X:307969 | Q>H | B:239 | (42.56, 46.03, 128.26) | |
| X:307491 | P>L | B:246 | (30.35, 47.67, 120.72) | |
| X:307488 | G>E | B:247 | (32.56, 45.07, 118.66) | |
| X:307477 | L>V | B:251 | (36.99, 39.73, 123.27) | |
| X:307470 | E>A | B:253 | (35.76, 36.97, 129.74) | |
| X:307462 | E>K | B:256 | (43.72, 32.58, 123.35) | |
| X:307447 | Y>H | B:261 | (42.48, 42.75, 119.36) | |
| X:307442 | I>M | B:262 | (45.74, 43.59, 122.93) | |
| X:307437 | T>M | B:264 | (47.72, 42.12, 116.89) | |
| X:306980 | F>V | B:270 | (54.75, 50.33, 117.32) | |
| X:306973 | A>V | B:272 | (52.48, 52.55, 110.91) | |
| X:306964 | R>Q | B:275 | (58.38, 54.11, 109.27) | |
| X:306941 | C>R | B:283 | (55.28, 63.00, 119.31) | |
| X:306919 | S>C | B:290 | (46.20, 57.86, 111.35) | |
| X:306407 | N>H | B:294 | (41.62, 55.75, 113.86) | |
| X:306400 | COSM3694550 COSM3694549 |
A>V | B:296 | (38.11, 59.28, 117.28) |
| X:306397 | L>Q | B:297 | (36.65, 57.26, 114.01) | |
| X:306388 | E>A | B:300 | (31.82, 58.13, 115.42) | |
| X:306385 | E>A | B:301 | (32.07, 52.99, 113.26) | |
| X:306373 | N>S | B:305 | (35.60, 45.25, 111.03) | |
| X:306369 | Q>H | B:306 | (34.17, 49.68, 108.88) | |
| X:306364 | T>I | B:308 | (40.99, 48.92, 108.24) | |
| X:306365 | T>A | B:308 | (40.99, 48.92, 108.24) | |
| X:306362 | E>K | B:309 | (44.23, 52.06, 109.57) | |
| X:306347 | E>K | B:314 | (38.01, 41.02, 109.68) | |
| X:306337 | Y>C | B:317 | (39.89, 34.92, 113.25) | |
| X:306330 | I>M | B:319 | (46.82, 37.66, 111.71) | |
| X:306329 | Y>H | B:320 | (45.70, 33.57, 116.62) | |
| X:306313 | E>V | B:325 | (47.63, 27.09, 110.78) | |
| X:306304 | COSM1119921 COSM1599271 |
T>M | B:328 | (51.43, 22.62, 116.20) |
| X:306281 | A>T | B:336 | (61.71, 27.46, 109.78) | |
| X:306273 | D>E | B:338 | (56.87, 25.97, 111.63) | |
| X:306275 | D>N | B:338 | (56.87, 25.97, 111.63) | |
| X:306269 | A>S | B:340 | (57.67, 26.95, 105.47) | |
| X:306266 | R>G | B:341 | (54.68, 24.22, 107.93) | |
| X:306263 | H>Y | B:342 | (52.60, 30.75, 105.26) | |
| X:306255 | D>E | B:344 | (50.77, 25.77, 100.60) | |
| X:306251 | A>T | B:346 | (55.04, 30.26, 98.95) | |
| X:302664 | rs190650453 | L>I | B:347 | (57.79, 32.18, 100.87) |
| X:302658 | T>A | B:349 | (63.83, 28.02, 101.83) | |
| X:302646 | D>N | B:353 | (66.91, 31.26, 106.44) | |
| X:302630 | G>E | B:358 | (68.51, 39.81, 111.80) | |
| X:302622 | T>A | B:361 | (64.86, 40.76, 114.49) | |
| X:302618 | R>Q | B:362 | (64.15, 44.81, 117.82) | |
| X:302129 | G>D | B:363 | (69.00, 41.14, 118.59) | |
| X:302130 | G>S | B:363 | (69.00, 41.14, 118.59) | |
| X:302112 | E>K | B:369 | (66.48, 30.64, 119.68) | |
| X:302108 | G>E | B:370 | (65.15, 29.93, 115.22) | |
| X:302105 | K>T | B:371 | (62.74, 29.70, 117.77) | |
| X:302101 | I>M | B:372 | (59.62, 33.93, 115.34) | |
| X:302091 | D>N | B:376 | (58.13, 38.86, 115.34) | |
| X:302074 | L>F | B:381 | (51.32, 37.90, 107.76) | |
| X:302069 | S>C | B:383 | (54.94, 42.23, 105.13) | |
| X:302064 | E>K | B:385 | (48.91, 40.30, 103.79) | |
| X:302061 | D>N | B:386 | (50.90, 44.78, 101.53) | |
| X:302048 | P>L | B:390 | (56.56, 51.82, 103.26) | |
| X:302049 | P>S | B:390 | (56.56, 51.82, 103.26) | |
| X:301674 | I>V | B:393 | (59.52, 48.02, 100.70) | |
| X:301670 | E>G | B:394 | (61.83, 49.27, 105.03) | |
| X:301668 | Y>D | B:395 | (60.37, 42.50, 106.72) | |
| X:301635 | G>S | B:406 | (72.35, 48.75, 100.12) | |
| X:301632 | A>T | B:407 | (72.65, 46.92, 97.42) | |
| X:301629 | L>V | B:408 | (69.89, 44.46, 95.77) | |
| X:301622 | rs147635089 | M>T | B:410 | (74.13, 39.91, 89.72) |
| X:301623 | M>V | B:410 | (74.13, 39.91, 89.72) | |
| X:301617 | E>K | B:412 | (72.47, 39.81, 96.69) | |
| X:301611 | E>K | B:414 | (72.04, 34.70, 90.58) | |
| X:301598 | E>G | B:418 | (68.52, 28.93, 92.47) | |
| X:301586 | COSM357136 | R>Q | B:422 | (65.64, 24.72, 92.45) |
| X:301582 | R>S | B:423 | (59.81, 26.83, 94.12) | |
| X:301569 | A>S | B:428 | (56.43, 22.19, 84.33) | |
| X:301554 | P>S | B:433 | (66.21, 33.27, 81.60) | |
| X:301547 | Q>R | B:435 | (70.52, 37.49, 82.20) | |
| X:301531 | Q>H | B:440 | (61.29, 42.13, 83.61) | |
| X:301518 | V>F | B:445 | (63.05, 49.28, 89.35) | |
| X:301511 | P>L | B:447 | (67.49, 52.04, 88.68) | |
| X:301503 | rs143981535 | E>K | B:450 | (74.50, 52.35, 85.97) |
| X:299607 | K>R | B:459 | (60.53, 53.19, 98.84) | |
| X:299604 | rs141968088 | R>H | B:460 | (61.56, 57.13, 94.24) |
| X:299605 | rs185988850 | R>C | B:460 | (61.56, 57.13, 94.24) |
| X:299598 | K>R | B:462 | (54.75, 53.02, 92.40) | |
| X:299596 | L>V | B:463 | (55.64, 47.54, 90.73) | |
| X:299592 | A>V | B:464 | (57.87, 46.12, 94.77) | |
| X:299593 | A>T | B:464 | (57.87, 46.12, 94.77) | |
| X:299589 | N>S | B:465 | (54.66, 43.87, 94.48) | |
| X:299587 | V>I | B:466 | (56.10, 42.41, 91.12) | |
| X:299584 | F>V | B:467 | (61.83, 43.01, 92.72) | |
| X:299578 | rs144771108 | D>N | B:469 | (56.52, 38.13, 94.46) |
| X:299560 | E>K | B:475 | (50.91, 31.10, 94.93) |