General Structure Information
| PDB ID | 2pid |
| HGNC Gene Label(s) | YARS2 |
| Structure Name | crystal structure of human mitochondrial tyrosyl-trna synthetase in complex with an adenylate analog |
| Resolution | 2.2Å |
| Reference | AUTH L.BONNEFOND,M.FRUGIER,E.TOUZE,B.LORBER,C.FLORENTZ,R.GIEGE,AUTH 2 C.SAUTER,J.RUDINGER-THIRIONTITL CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL TYROSYL-TRNATITL 2 SYNTHETASE REVEALS COMMON AND IDIOSYNCRATIC FEATURES.REF STRUCTURE V. 15 1505 2007REFN ISSN 0969-2126PMID 17997975DOI 10.1016/J.STR.2007.09.018 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 317 |
| Number Of SNVs | 68 |
| Number Of Permutations | 14048 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.332 |
| p-value | 0.163 |
COSMIC
| Number Of Residues | 317 |
| Number Of SNVs | 4 |
| Number Of Permutations | 283 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 68 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | -0.226 |
| p-value | 0.923 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
