General Structure Information
| PDB ID | 3l8n |
| HGNC Gene Label(s) | ARFGEF2 |
| Structure Name | crystal structure of a domain of brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldina-inhibited gep 2) from homo sapiens (human). northeast structural genomics consortium target id hr5562a |
| Resolution | 2.86Å |
| Reference | AUTH J.SEETHARAMAN,M.SU,F.FOROUHAR,D.WANG,H.JANJUA,AUTH 2 K.CUNNINGHAM,L.OWENS,R.XIAO,J.LIU,M.C.BARAN,AUTH 3 T.B.ACTON,G.T.MONTELIONE,J.F.HUNT,L.TONGTITL CRYSTAL STRUCTURE OF A DOMAIN OF BREFELDINTITL 2 A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 2TITL 3 (BREFELDINA-INHIBITED GEP 2) FROM HOMO SAPIENSTITL 4 (HUMAN). NORTHEAST STRUCTURAL GENOMICS CONSORTIUMTITL 5 TARGET ID HR5562AREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 173 |
| Number Of SNVs | 29 |
| Number Of Permutations | 20175 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.32 |
| p-value | 0.221 |
COSMIC
| Number Of Residues | 173 |
| Number Of SNVs | 3 |
| Number Of Permutations | 254 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.667 |
| p-value | 0.783 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.446 |
| p-value | 0.522 |