General Structure Information
| PDB ID | 4nh3 |
| HGNC Gene Label(s) | DICER1 |
| Structure Name | structure of human dicer platform-paz-connector helix cassette in complex with 13-mer sirna having 5-pu and uu-3 ends (2.6 angstrom resolution) |
| Resolution | 2.62Å |
| Reference | AUTH Y.TIAN,D.K.SIMANSHU,J.B.MA,J.E.PARK,I.HEO,V.N.KIM,D.J.PATELTITL A PHOSPHATE-BINDING POCKET WITHIN THE PLATFORM-PAZ-CONNECTORTITL 2 HELIX CASSETTE OF HUMAN DICER.REF MOL.CELL V. 53 606 2014REFN ISSN 1097-2765PMID 24486018DOI 10.1016/J.MOLCEL.2014.01.003 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 268 |
| Number Of SNVs | 24 |
| Number Of Permutations | 14368 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.196 |
| p-value | 0.064 |
COSMIC
| Number Of Residues | 268 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3693 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.286 |
| p-value | 0.839 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.204 |
| p-value | 0.205 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
