General Structure Information
| PDB ID | 2wtk |
| HGNC Gene Label(s) | CAB39 |
| Structure Name | structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex |
| Resolution | 2.65Å |
| Reference | AUTH E.ZEQIRAJ,B.M.FILIPPI,M.DEAK,D.R.ALESSI,D.M.F.VAN AALTENTITL STRUCTURE OF THE LKB1-STRAD-MO25 COMPLEX REVEALS ANTITL 2 ALLOSTERIC MECHANISM OF KINASE ACTIVATION.REF SCIENCE V. 326 1707 2009REFN ISSN 0036-8075PMID 19892943DOI 10.1126/SCIENCE.1178377 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 321 |
| Number Of SNVs | 48 |
| Number Of Permutations | 13314 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.258 |
| p-value | 0.121 |
COSMIC
| Number Of Residues | 321 |
| Number Of SNVs | 4 |
| Number Of Permutations | 708 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.167 |
| p-value | 0.721 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 48 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 38.0 |
| K Statistic | -0.224 |
| p-value | 0.871 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
