General Structure Information
| PDB ID | 2w0u |
| HGNC Gene Label(s) | HAO1 |
| Structure Name | crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]- 1,2,3-thiadiazole-4-carboxylate. |
| Resolution | 2.84Å |
| Reference | AUTH J.M.BOURHIS,C.VIGNAUD,N.PIETRANCOSTA,F.GUERITTE,AUTH 2 D.GUENARD,F.LEDERER,Y.LINDQVISTTITL STRUCTURE OF HUMAN GLYCOLATE OXIDASE IN COMPLEXTITL 2 WITH THE INHIBITOR 4-CARBOXY-5-[(4-TITL 3 CHLOROPHENYL)SULFANYL]-1,2,3-THIADIAZOLE.REF ACTA CRYSTALLOGR.,SECT.F V. 65 1246 2009REFN ISSN 1744-3091PMID 20054120DOI 10.1107/S1744309109041670 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 332 |
| Number Of SNVs | 99 |
| Number Of Permutations | 42078 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.223 |
| p-value | 0.064 |
COSMIC
| Number Of Residues | 332 |
| Number Of SNVs | 11 |
| Number Of Permutations | 3193 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.145 |
| p-value | 0.014 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 99 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.231 |
| p-value | 0.074 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
