General Structure Information
| PDB ID | 2iwi |
| HGNC Gene Label(s) | PIM2 |
| Structure Name | crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1 |
| Resolution | 2.8Å |
| Reference | AUTH A.N.BULLOCK,S.RUSSO,A.AMOS,N.PAGANO,H.BREGMAN,AUTH 2 J.E.DEBRECZENI,W.H.LEE,F.VON DELFT,E.MEGGERS,AUTH 3 S.KNAPPTITL CRYSTAL STRUCTURE OF THE PIM2 KINASE IN COMPLEXTITL 2 WITH AN ORGANORUTHENIUM INHIBITOR.REF PLOS ONE V. 4 E7112 2009REFN ISSN 1932-6203PMID 19841674DOI 10.1371/JOURNAL.PONE.0007112 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 244 |
| Number Of SNVs | 26 |
| Number Of Permutations | 3663 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.009 |
| p-value | 0.744 |
COSMIC
| Number Of Residues | 244 |
| Number Of SNVs | 3 |
| Number Of Permutations | 189 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.333 |
| p-value | 0.205 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 26 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.324 |
| p-value | 0.276 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
