General Structure Information
| PDB ID | 3mdj |
| HGNC Gene Label(s) | ERAP1 |
| Structure Name | er aminopeptidase, erap1, bound to the zinc aminopeptidase inhibitor, bestatin |
| Resolution | 2.95Å |
| Reference | AUTH T.T.NGUYEN,S.C.CHANG,I.EVNOUCHIDOU,I.A.YORK,C.ZIKOS,AUTH 2 K.L.ROCK,A.L.GOLDBERG,E.STRATIKOS,L.J.STERNTITL STRUCTURAL BASIS FOR ANTIGENIC PEPTIDE PRECURSOR PROCESSINGTITL 2 BY THE ENDOPLASMIC RETICULUM AMINOPEPTIDASE ERAP1.REF NAT.STRUCT.MOL.BIOL. V. 18 604 2011REFN ISSN 1545-9993PMID 21478864DOI 10.1038/NSMB.2021 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 819 |
| Number Of SNVs | 224 |
| Number Of Permutations | 56771 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.051 |
| p-value | 0.879 |
COSMIC
| Number Of Residues | 819 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1512 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.133 |
| p-value | 0.979 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 224 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 35.0 |
| K Statistic | 0.483 |
| p-value | 0.109 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 5:96139477 | K>N | C:51 | (-17.78, 117.44, -58.02) | |
| 5:96139472 | rs369776125 | R>Q | C:53 | (-14.38, 116.85, -52.13) |
| 5:96139464 | rs3734016 | E>K | C:56 | (-9.31, 112.30, -56.82) |
| 5:96139458 | rs376575167 | V>I | C:58 | (-4.39, 117.15, -59.80) |
| 5:96139449 | V>L | C:61 | (4.12, 118.88, -53.91) | |
| 5:96139445 | H>R | C:62 | (6.31, 123.53, -52.80) | |
| 5:96139428 | rs138846351 | H>Y | C:68 | (3.01, 143.44, -51.44) |
| 5:96139412 | T>M | C:73 | (-4.35, 150.61, -49.45) | |
| 5:96139394 | COSM149892 | T>I | C:79 | (3.29, 135.34, -57.04) |
| 5:96139395 | rs151040768 | T>A | C:79 | (3.29, 135.34, -57.04) |
| 5:96139391 | T>M | C:80 | (1.19, 131.60, -56.07) | |
| 5:96139380 | I>V | C:84 | (1.42, 120.05, -60.16) | |
| 5:96139367 | Q>L | C:88 | (-5.86, 110.75, -64.34) | |
| 5:96139361 | T>I | C:90 | (-5.61, 116.14, -67.55) | |
| 5:96139357 | S>R | C:91 | (-6.29, 119.81, -69.86) | |
| 5:96139350 | I>V | C:94 | (-9.97, 122.20, -60.80) | |
| 5:96139336 | H>Q | C:98 | (-13.48, 133.65, -52.19) | |
| 5:96139323 | S>P | C:103 | (-3.55, 138.86, -63.55) | |
| 5:96139283 | S>L | C:116 | (8.15, 125.70, -71.30) | |
| 5:96139284 | S>P | C:116 | (8.15, 125.70, -71.30) | |
| 5:96139281 | E>K | C:117 | (6.42, 129.92, -69.34) | |
| 5:96139257 | H>Y | C:125 | (-18.16, 128.03, -60.09) | |
| 5:96139254 | P>S | C:126 | (-17.99, 131.82, -57.92) | |
| 5:96139233 | L>V | C:133 | (-6.20, 126.39, -64.74) | |
| 5:96139221 | E>K | C:137 | (-0.40, 120.53, -74.69) | |
| 5:96139217 | P>L | C:138 | (-2.27, 117.24, -72.50) | |
| 5:96139205 | rs561662269 | G>V | C:142 | (4.44, 112.07, -63.50) |
| 5:96139206 | rs149653730 | G>R | C:142 | (4.44, 112.07, -63.50) |
| 5:96139199 | rs140515309 | P>L | C:144 | (7.02, 117.46, -62.94) |
| 5:96139169 | rs201670295 | N>S | C:154 | (-9.18, 143.92, -51.18) |
| 5:96139157 | T>N | C:158 | (-14.86, 139.34, -42.15) | |
| 5:96139145 | F>C | C:162 | (-4.58, 138.49, -45.43) | |
| 5:96136700 | I>M | C:176 | (-3.43, 148.61, -39.16) | |
| 5:96136690 | T>A | C:180 | (-4.17, 134.57, -40.99) | |
| 5:96136684 | F>L | C:182 | (-6.59, 130.45, -43.72) | |
| 5:96136677 | rs142482678 | P>R | C:184 | (-12.45, 126.01, -42.74) |
| 5:96136674 | rs538001747 | T>I | C:185 | (-12.60, 127.27, -46.48) |
| 5:96136672 | A>T | C:186 | (-9.79, 130.74, -46.05) | |
| 5:96136668 | rs139782060 | A>G | C:187 | (-6.90, 129.91, -47.93) |
| 5:96136661 | M>I | C:189 | (-9.75, 134.56, -48.99) | |
| 5:96136659 | A>V | C:190 | (-4.90, 134.47, -49.85) | |
| 5:96136639 | P>A | C:197 | (-7.53, 118.77, -45.70) | |
| 5:96136632 | rs146396644 | F>C | C:199 | (-5.03, 118.02, -51.55) |
| 5:96136622 | S>R | C:202 | (5.51, 122.39, -48.95) | |
| 5:96136623 | rs577150352 | S>N | C:202 | (5.51, 122.39, -48.95) |
| 5:96136615 | rs200284630 | I>V | C:205 | (5.89, 131.77, -47.01) |
| 5:96136611 | K>R | C:206 | (8.17, 134.57, -50.04) | |
| 5:96136596 | P>R | C:211 | (10.18, 149.11, -42.44) | |
| 5:96136591 | H>Y | C:213 | (5.04, 146.75, -40.26) | |
| 5:96136572 | rs112160177 | M>T | C:219 | (8.52, 127.92, -40.37) |
| 5:96136569 | rs142097626 | P>L | C:220 | (11.48, 130.05, -38.96) |
| 5:96136566 | L>W | C:221 | (13.05, 134.81, -40.65) | |
| 5:96133012 | V>L | C:222 | (15.79, 132.58, -43.33) | |
| 5:96132994 | A>S | C:228 | (12.51, 148.45, -52.11) | |
| 5:96132973 | H>Y | C:235 | (12.78, 135.04, -47.63) | |
| 5:96132947 | S>R | C:243 | (-2.78, 121.44, -44.36) | |
| 5:96132914 | F>L | C:254 | (2.42, 142.70, -32.62) | |
| 5:96132901 | rs143271510 | K>E | C:259 | (11.09, 130.27, -22.04) |
| 5:96132889 | S>C | C:263 | (14.00, 120.77, -26.31) | |
| 5:96132885 | G>E | C:264 | (15.16, 124.10, -27.81) | |
| 5:96130859 | rs576554860 | V>I | C:269 | (4.27, 135.71, -26.65) |
| 5:96130846 | P>L | C:273 | (3.26, 147.00, -27.85) | |
| 5:96130842 | D>E | C:274 | (1.02, 148.82, -25.07) | |
| 5:96130836 | rs26618 | I>M | C:276 | (4.26, 142.37, -24.12) |
| 5:96130814 | rs112686030 | D>N | C:284 | (5.45, 129.65, -17.88) |
| 5:96130807 | rs367650672 COSM3857014 |
A>V | C:286 | (3.59, 127.11, -23.02) |
| 5:96130804 | V>G | C:287 | (7.22, 126.17, -21.80) | |
| 5:96130769 | rs118132132 | I>L | C:299 | (6.56, 112.91, -30.79) |
| 5:96130765 | rs370484274 | P>L | C:300 | (9.68, 115.44, -30.96) |
| 5:96130757 | L>I | C:303 | (7.94, 122.78, -35.91) | |
| 5:96130754 | P>T | C:304 | (11.49, 125.00, -35.30) | |
| 5:96130748 | Q>K | C:306 | (5.11, 127.91, -30.88) | |
| 5:96129652 | A>P | C:310 | (-2.41, 138.33, -29.36) | |
| 5:96129641 | D>E | C:313 | (-10.67, 142.55, -33.02) | |
| 5:96129643 | D>N | C:313 | (-10.67, 142.55, -33.02) | |
| 5:96129635 | COSM4137900 | Q>H | C:315 | (-13.97, 137.22, -33.81) |
| 5:96129631 | rs574810839 | G>S | C:317 | (-10.58, 132.37, -30.57) |
| 5:96129625 | rs556623443 | M>V | C:319 | (-6.39, 128.54, -34.77) |
| 5:96129617 | rs147839365 | N>K | C:321 | (-2.19, 128.21, -36.91) |
| 5:96129619 | N>D | C:321 | (-2.19, 128.21, -36.91) | |
| 5:96129612 | G>E | C:323 | (3.82, 127.67, -35.09) | |
| 5:96129607 | rs544240020 | T>S | C:325 | (-1.07, 129.86, -32.04) |
| 5:96129598 | rs371320592 | R>G | C:328 | (-9.72, 134.89, -26.80) |
| 5:96129588 | A>V | C:331 | (-6.86, 133.90, -24.09) | |
| 5:96129558 | rs373383275 | A>V | C:341 | (-9.79, 133.86, -11.78) |
| 5:96129543 | rs27895 | G>D | C:346 | (-9.69, 130.65, -20.10) |
| 5:96129541 | I>V | C:347 | (-5.23, 131.56, -20.38) | |
| 5:96129535 | rs2287987 | M>V | C:349 | (-7.82, 125.28, -20.56) |
| 5:96129520 | E>K | C:354 | (-4.91, 125.45, -29.69) | |
| 5:96129508 | rs113607082 | Q>E | C:358 | (0.87, 121.77, -32.76) |
| 5:96129206 | N>I | C:362 | (-1.46, 119.92, -37.17) | |
| 5:96129189 | W>R | C:368 | (-13.84, 116.40, -45.60) | |
| 5:96129183 | N>H | C:370 | (-15.90, 113.56, -41.36) | |
| 5:96129172 | W>C | C:373 | (-15.42, 113.53, -33.86) | |
| 5:96129161 | G>V | C:377 | (-11.96, 116.21, -28.63) | |
| 5:96129159 | F>L | C:378 | (-7.12, 114.30, -28.38) | |
| 5:96129147 | M>V | C:382 | (-5.24, 116.40, -23.95) | |
| 5:96129137 | V>A | C:385 | (-4.48, 115.08, -19.42) | |
| 5:96127880 | G>S | C:402 | (-19.88, 119.25, -16.65) | |
| 5:96127868 | rs181668902 | D>N | C:406 | (-23.71, 119.92, -20.03) |
| 5:96127864 | A>V | C:407 | (-23.74, 116.48, -23.09) | |
| 5:96127865 | rs376696268 | A>T | C:407 | (-23.74, 116.48, -23.09) |
| 5:96127860 | M>I | C:408 | (-25.46, 113.34, -20.86) | |
| 5:96127862 | rs375684249 | M>V | C:408 | (-25.46, 113.34, -20.86) |
| 5:96127855 | rs573281746 | V>E | C:410 | (-28.04, 117.53, -25.28) |
| 5:96127778 | V>I | C:436 | (-21.64, 119.81, -27.15) | |
| 5:96127767 | D>E | C:439 | (-17.82, 118.34, -25.04) | |
| 5:96127766 | rs372779997 | K>E | C:440 | (-20.08, 112.78, -26.92) |
| 5:96126345 | G>E | C:441 | (-15.57, 113.33, -27.31) | |
| 5:96126327 | M>T | C:447 | (-15.27, 105.88, -21.63) | |
| 5:96126328 | rs184320964 | M>V | C:447 | (-15.27, 105.88, -21.63) |
| 5:96126318 | E>G | C:450 | (-10.08, 105.40, -17.36) | |
| 5:96126307 | rs140121905 | A>T | C:454 | (-3.44, 105.28, -19.37) |
| 5:96126301 | rs150674566 | A>T | C:456 | (-2.62, 101.91, -23.25) |
| 5:96126294 | rs563590135 | K>I | C:458 | (0.74, 107.30, -23.44) |
| 5:96126295 | rs141891516 | K>E | C:458 | (0.74, 107.30, -23.44) |
| 5:96126291 | S>N | C:459 | (0.69, 103.68, -26.53) | |
| 5:96126288 | G>V | C:460 | (-1.72, 104.36, -29.11) | |
| 5:96126289 | G>R | C:460 | (-1.72, 104.36, -29.11) | |
| 5:96126278 | Q>H | C:463 | (1.27, 103.09, -32.72) | |
| 5:96126243 | N>T | C:475 | (-12.68, 107.85, -37.39) | |
| 5:96126241 | E>K | C:476 | (-11.66, 103.17, -38.91) | |
| 5:96126225 | S>T | C:481 | (-3.70, 102.37, -33.42) | |
| 5:96126216 | S>N | C:484 | (-2.61, 97.42, -31.57) | |
| 5:96126070 | rs199837380 | I>V | C:485 | (-1.48, 98.01, -27.71) |
| 5:96124355 | M>V | C:520 | (-16.25, 100.05, -28.58) | |
| 5:96124350 | rs567477737 | M>I | C:521 | (-15.68, 103.80, -30.25) |
| 5:96124330 | rs30187 | K>R | C:528 | (-29.77, 109.44, -30.92) |
| 5:96124327 | G>D | C:529 | (-26.81, 108.74, -27.53) | |
| 5:96124325 | F>L | C:530 | (-26.89, 108.26, -23.04) | |
| 5:96124300 | rs142305981 | R>K | C:538 | (-30.54, 88.24, -7.96) |
| 5:96124292 | N>H | C:541 | (-24.86, 86.07, -10.00) | |
| 5:96124289 | rs370389549 | V>I | C:542 | (-23.60, 90.82, -11.48) |
| 5:96124282 | M>T | C:544 | (-24.84, 93.81, -17.09) | |
| 5:96124279 | K>T | C:545 | (-30.58, 96.08, -18.98) | |
| 5:96124273 | E>G | C:547 | (-32.07, 100.67, -21.55) | |
| 5:96124269 | H>Q | C:548 | (-31.69, 105.07, -26.00) | |
| 5:96124265 | M>V | C:550 | (-35.12, 107.77, -24.32) | |
| 5:96124247 | rs61734613 | A>T | C:556 | (-43.02, 106.16, -27.15) |
| 5:96124243 | rs182529691 | P>L | C:557 | (-40.81, 104.59, -25.28) |
| 5:96124238 | T>A | C:559 | (-34.89, 102.37, -29.39) | |
| 5:96124234 | rs371023602 | G>V | C:560 | (-32.46, 99.50, -30.59) |
| 5:96122236 | P>L | C:566 | (-16.84, 100.45, -21.43) | |
| 5:96122209 | rs6863093 | D>G | C:575 | (-8.77, 97.01, -3.42) |
| 5:96122210 | rs10050860 | D>N | C:575 | (-8.77, 97.01, -3.42) |
| 5:96122204 | V>F | C:577 | (-10.82, 99.17, -10.87) | |
| 5:96122183 | T>S | C:584 | (-24.98, 92.15, -25.21) | |
| 5:96122179 | K>I | C:585 | (-30.00, 94.37, -23.97) | |
| 5:96121672 | rs114703312 | V>G | C:588 | (-23.71, 87.62, -16.16) |
| 5:96121667 | I>L | C:590 | (-19.51, 85.63, -11.48) | |
| 5:96121661 | P>S | C:592 | (-15.64, 86.10, -5.76) | |
| 5:96121628 | rs189721036 | G>S | C:603 | (-15.36, 108.36, -11.51) |
| 5:96121625 | M>V | C:604 | (-18.15, 110.45, -13.26) | |
| 5:96121613 | Y>H | C:608 | (-21.98, 104.73, -18.29) | |
| 5:96121596 | rs149374891 | E>D | C:613 | (-33.02, 96.25, -9.64) |
| 5:96121583 | rs201856260 | D>Y | C:618 | (-31.14, 101.30, -0.07) |
| 5:96121580 | S>T | C:619 | (-26.51, 100.25, -0.23) | |
| 5:96121571 | G>S | C:622 | (-25.85, 104.06, 3.31) | |
| 5:96121543 | V>G | C:631 | (-16.69, 106.48, -2.59) | |
| 5:96121528 | rs144333828 | R>Q | C:636 | (-19.17, 111.30, -3.07) |
| 5:96121529 | COSM3702863 | R>W | C:636 | (-19.17, 111.30, -3.07) |
| 5:96121525 | A>V | C:637 | (-21.66, 113.06, -7.89) | |
| 5:96121526 | rs530052485 COSM3857013 |
A>T | C:637 | (-21.66, 113.06, -7.89) |
| 5:96121523 | S>R | C:638 | (-22.64, 110.06, -9.93) | |
| 5:96121512 | N>K | C:641 | (-26.71, 112.96, -11.58) | |
| 5:96121496 | rs111363347 | V>I | C:647 | (-36.65, 110.58, -10.21) |
| 5:96119781 | I>M | C:649 | (-37.10, 108.52, -15.96) | |
| 5:96119782 | rs147252760 | I>T | C:649 | (-37.10, 108.52, -15.96) |
| 5:96119779 | G>E | C:650 | (-39.64, 106.71, -13.24) | |
| 5:96119774 | L>V | C:652 | (-35.81, 106.49, -8.48) | |
| 5:96119759 | A>T | C:657 | (-33.18, 110.99, -3.89) | |
| 5:96119746 | rs377644216 | S>F | C:661 | (-29.61, 114.16, -0.12) |
| 5:96119740 | rs143726979 | Y>C | C:663 | (-24.61, 112.76, 0.84) |
| 5:96119722 | E>G | C:669 | (-15.49, 117.73, -1.78) | |
| 5:96119717 | M>V | C:671 | (-18.90, 118.20, -8.21) | |
| 5:96119713 | P>H | C:672 | (-20.80, 116.79, -4.74) | |
| 5:96119710 | V>E | C:673 | (-22.71, 120.42, -3.32) | |
| 5:96119693 | E>K | C:679 | (-31.13, 118.56, -9.49) | |
| 5:96119681 | M>V | C:683 | (-37.35, 121.24, -6.56) | |
| 5:96119677 | Y>C | C:684 | (-36.52, 126.60, -4.08) | |
| 5:96119669 | M>V | C:687 | (-42.39, 125.30, -4.49) | |
| 5:96119665 | E>V | C:688 | (-40.76, 130.61, -5.08) | |
| 5:96119655 | D>E | C:691 | (-50.82, 128.94, -2.61) | |
| 5:96119653 | M>T | C:692 | (-48.79, 125.27, -0.92) | |
| 5:96118914 | D>V | C:709 | (-22.19, 122.38, 8.76) | |
| 5:96118915 | D>N | C:709 | (-22.19, 122.38, 8.76) | |
| 5:96118908 | rs138598123 | I>T | C:711 | (-22.94, 127.75, 5.11) |
| 5:96118909 | I>L | C:711 | (-22.94, 127.75, 5.11) | |
| 5:96118904 | D>E | C:712 | (-20.77, 127.59, 8.95) | |
| 5:96118885 | E>K | C:719 | (-9.34, 132.34, -0.04) | |
| 5:96118857 | rs201805082 | R>Q | C:728 | (-16.52, 131.33, -0.95) |
| 5:96118852 | rs27044 | Q>E | C:730 | (-23.79, 130.91, -5.18) |
| 5:96118837 | A>T | C:735 | (-28.15, 131.90, 3.20) | |
| 5:96118832 | rs200156544 | C>W | C:736 | (-28.50, 135.51, 3.13) |
| 5:96118833 | C>Y | C:736 | (-28.50, 135.51, 3.13) | |
| 5:96118834 | rs375081137 | C>R | C:736 | (-28.50, 135.51, 3.13) |
| 5:96118810 | rs370949768 | V>I | C:744 | (-27.98, 137.68, 7.55) |
| 5:96118775 | rs145659288 | K>N | C:755 | (-23.96, 153.05, 4.29) |
| 5:96118771 | S>P | C:757 | (-17.05, 153.89, 3.63) | |
| 5:96118764 | G>E | C:759 | (-17.45, 152.51, -0.95) | |
| 5:96118755 | S>T | C:762 | (-12.52, 146.84, -0.36) | |
| 5:96117547 | rs375467336 | D>A | C:766 | (-16.54, 135.84, -3.37) |
| 5:96117548 | rs151103435 | D>N | C:766 | (-16.54, 135.84, -3.37) |
| 5:96117541 | T>N | C:768 | (-20.43, 141.43, -2.80) | |
| 5:96117537 | L>F | C:769 | (-23.95, 138.75, -4.56) | |
| 5:96117527 | A>S | C:773 | (-28.65, 141.41, -1.07) | |
| 5:96117518 | A>S | C:776 | (-31.31, 146.11, -0.43) | |
| 5:96117511 | S>I | C:778 | (-32.84, 148.74, 3.47) | |
| 5:96117506 | E>Q | C:780 | (-31.70, 153.11, 4.34) | |
| 5:96117497 | D>N | C:783 | (-31.91, 154.39, -2.21) | |
| 5:96117485 | rs554410467 | S>G | C:787 | (-26.15, 155.98, -5.93) |
| 5:96117457 | T>I | C:796 | (-18.59, 142.78, -11.74) | |
| 5:96117443 | I>V | C:801 | (-25.65, 146.47, -7.68) | |
| 5:96117404 | L>F | C:814 | (-39.43, 146.06, -7.56) | |
| 5:96117398 | W>R | C:816 | (-38.43, 153.51, -9.61) | |
| 5:96116897 | rs138617866 | L>R | C:818 | (-39.96, 147.64, -14.12) |
| 5:96116895 | rs371817031 | D>N | C:819 | (-41.33, 151.96, -14.86) |
| 5:96116890 | E>D | C:820 | (-37.76, 154.46, -14.32) | |
| 5:96116879 | G>A | C:824 | (-34.38, 157.12, -21.09) | |
| 5:96116846 | I>T | C:835 | (-34.22, 144.42, -14.71) | |
| 5:96116834 | rs147939272 | I>T | C:839 | (-38.12, 141.35, -10.80) |
| 5:96116820 | V>L | C:844 | (-42.64, 139.32, -4.08) | |
| 5:96116816 | G>A | C:845 | (-42.14, 140.06, -8.37) | |
| 5:96116799 | rs140865304 | Q>K | C:851 | (-49.23, 142.40, -13.43) |
| 5:96116774 | K>T | C:859 | (-45.79, 151.12, -26.07) | |
| 5:96116762 | K>R | C:863 | (-38.02, 148.14, -27.94) | |
| 5:96116195 | S>P | C:868 | (-37.92, 139.33, -31.91) | |
| 5:96116180 | H>Y | C:873 | (-34.37, 136.49, -21.45) | |
| 5:96116171 | M>V | C:876 | (-38.27, 131.97, -21.02) | |
| 5:96116168 | G>S | C:877 | (-38.41, 134.75, -17.32) | |
| 5:96116161 | T>K | C:879 | (-43.44, 132.31, -17.82) | |
| 5:96116140 | rs548815514 | T>I | C:886 | (-54.63, 128.48, -13.50) |
| 5:96116137 | rs200571600 | R>Q | C:887 | (-50.46, 131.45, -13.36) |
| 5:96116138 | rs371393983 | R>W | C:887 | (-50.46, 131.45, -13.36) |
| 5:96112206 | C>F | C:907 | (-40.61, 132.01, -30.91) | |
| 5:96112207 | rs373000476 | C>R | C:907 | (-40.61, 132.01, -30.91) |
| 5:96112194 | T>K | C:911 | (-42.28, 128.89, -22.61) | |
| 5:96112191 | I>T | C:912 | (-45.93, 126.80, -24.25) | |
| 5:96112187 | E>D | C:913 | (-43.03, 122.74, -24.40) | |
| 5:96112182 | rs139576768 | I>T | C:915 | (-45.35, 125.78, -18.05) |
| 5:96112174 | N>H | C:918 | (-43.30, 122.82, -14.53) | |
| 5:96112168 | rs200883678 | G>S | C:920 | (-46.31, 117.44, -13.90) |
| 5:96112157 | D>E | C:923 | (-49.68, 117.13, -10.73) | |
| 5:96112147 | D>N | C:927 | (-48.54, 115.34, -2.90) | |
| 5:96112137 | R>T | C:930 | (-47.50, 116.93, 1.65) | |
| 5:96112125 | Q>P | C:934 | (-44.12, 115.04, 7.37) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 5:96139461 | COSM1071469 | Y>H | C:57 | (-7.65, 114.14, -61.73) |
| 5:96139250 | COSM4418435 | R>L | C:127 | (-23.04, 129.02, -56.78) |
| 5:96129543 | COSM4407096 | G>D | C:346 | (-9.69, 130.65, -20.10) |
| 5:96126301 | COSM3141978 | A>T | C:456 | (-2.62, 101.91, -23.25) |
| 5:96126277 | COSM1642809 | Y>H | C:464 | (-2.89, 108.16, -34.90) |
| 5:96124330 | COSM4160065 | K>R | C:528 | (-29.77, 109.44, -30.92) |
| 5:96124278 | COSM1634385 | K>N | C:545 | (-30.58, 96.08, -18.98) |