General Structure Information
| PDB ID | 4im0 |
| HGNC Gene Label(s) | TBK1 |
| Structure Name | structure of tank-binding kinase 1 |
| Resolution | 2.4Å |
| Reference | AUTH D.TU,Z.ZHU,A.Y.ZHOU,C.YUN,K.LEE,A.V.TOMS,Y.LI,G.P.DUNN,AUTH 2 E.CHAN,T.THAI,S.YANG,S.B.FICARRO,J.A.MARTO,H.JEON,W.C.HAHN,AUTH 3 D.A.BARBIE,M.J.ECKTITL STRUCTURE OF TANK-BINDING KINASE 1REF CELL.REPORTS. 2013REFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 617 |
| Number Of SNVs | 123 |
| Number Of Permutations | 51818 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.066 |
| p-value | 0.134 |
COSMIC
| Number Of Residues | 617 |
| Number Of SNVs | 6 |
| Number Of Permutations | 4281 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.133 |
| p-value | 0.659 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 123 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.133 |
| p-value | 0.816 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 12:64849663 | COSM3781047 COSM3781048 |
S>T | A:5 | (122.89, 9.11, -43.36) |
| 12:64849664 | S>C | A:5 | (122.89, 9.11, -43.36) | |
| 12:64849684 | rs199822589 | S>A | A:12 | (119.30, 7.97, -23.64) |
| 12:64849685 | S>C | A:12 | (119.30, 7.97, -23.64) | |
| 12:64849688 | rs371540185 | D>G | A:13 | (118.46, 11.36, -25.36) |
| 12:64849690 | I>V | A:14 | (113.48, 8.97, -24.91) | |
| 12:64849700 | Q>R | A:17 | (107.59, 5.55, -25.46) | |
| 12:64849723 | COSM942503 COSM942504 |
R>C | A:25 | (118.24, 14.99, -27.65) |
| 12:64853990 | I>V | A:37 | (114.64, 11.00, -34.39) | |
| 12:64854006 | N>S | A:42 | (106.39, -3.41, -36.88) | |
| 12:64854029 | D>N | A:50 | (103.92, 2.33, -49.98) | |
| 12:64854065 | L>F | A:62 | (101.69, 19.99, -43.61) | |
| 12:64854068 | N>H | A:63 | (104.09, 24.98, -44.00) | |
| 12:64854098 | I>V | A:73 | (111.82, 9.73, -44.99) | |
| 12:64854101 | E>Q | A:74 | (116.34, 9.58, -43.23) | |
| 12:64854104 | E>K | A:75 | (116.83, 3.91, -44.73) | |
| 12:64858115 | T>I | A:77 | (122.08, 2.23, -40.44) | |
| 12:64858142 | M>T | A:86 | (110.09, 15.44, -36.78) | |
| 12:64858177 | L>I | A:98 | (100.04, 21.97, -17.15) | |
| 12:64858196 | A>G | A:104 | (98.22, 24.08, -10.45) | |
| 12:64858224 | L>F | A:113 | (95.09, 33.76, -24.81) | |
| 12:64858237 | rs200879808 | D>N | A:118 | (98.56, 28.26, -31.28) |
| 12:64860683 | rs562577505 COSM1513041 COSM1513040 |
G>S | A:121 | (95.21, 26.89, -36.01) |
| 12:64860690 | COSM1735095 COSM1735096 |
M>T | A:123 | (92.86, 21.88, -35.20) |
| 12:64860746 | M>L | A:142 | (104.77, 20.25, -28.64) | |
| 12:64860750 | R>H | A:143 | (106.76, 25.77, -25.02) | |
| 12:64860752 | V>I | A:144 | (108.50, 26.71, -29.29) | |
| 12:64860755 | I>V | A:145 | (110.69, 29.77, -27.40) | |
| 12:64860756 | I>T | A:145 | (110.69, 29.77, -27.40) | |
| 12:64860759 | rs41292021 | G>A | A:146 | (110.00, 32.36, -30.08) |
| 12:64860761 | rs372808630 | E>K | A:147 | (112.00, 35.63, -33.27) |
| 12:64860774 | rs55824172 | S>F | A:151 | (105.09, 30.60, -26.63) |
| 12:64860776 | rs202011771 | V>L | A:152 | (104.88, 28.65, -30.47) |
| 12:64868019 | M>V | A:184 | (85.64, 7.07, -27.21) | |
| 12:64868046 | D>N | A:193 | (81.94, 6.79, -40.03) | |
| 12:64868089 | rs200709730 | I>T | A:207 | (89.73, 20.83, -27.80) |
| 12:64868110 | A>V | A:214 | (94.77, 25.12, -19.04) | |
| 12:64868152 | COSM1299769 COSM1299768 |
R>H | A:228 | (91.44, 4.82, -13.98) |
| 12:64868166 | rs149881816 | V>L | A:233 | (82.36, 6.83, -12.15) |
| 12:64873794 | Y>F | A:235 | (80.00, 6.45, -19.64) | |
| 12:64873803 | I>T | A:238 | (80.86, 12.27, -19.29) | |
| 12:64873818 | S>C | A:243 | (73.29, 20.91, -20.25) | |
| 12:64873824 | A>V | A:245 | (78.17, 21.80, -17.63) | |
| 12:64873826 | I>V | A:246 | (82.21, 23.15, -17.57) | |
| 12:64873848 | E>A | A:253 | (84.47, 6.43, -1.57) | |
| 12:64873869 | S>N | A:260 | (79.91, 23.64, -12.75) | |
| 12:64873877 | rs373705051 COSM193834 COSM193835 |
M>V | A:263 | (85.64, 28.50, -14.32) |
| 12:64873883 | V>L | A:265 | (87.53, 30.59, -7.29) | |
| 12:64873892 | S>G | A:268 | (93.70, 33.09, -13.12) | |
| 12:64873902 | rs56196591 | R>Q | A:271 | (84.13, 36.58, -14.48) |
| 12:64875678 | E>G | A:290 | (72.04, 16.62, -32.40) | |
| 12:64875680 | rs34774243 | K>E | A:291 | (72.88, 20.26, -30.24) |
| 12:64875722 | I>V | A:305 | (87.89, 35.25, -27.91) | |
| 12:64875723 | I>T | A:305 | (87.89, 35.25, -27.91) | |
| 12:64875725 | rs201970436 | L>I | A:306 | (91.70, 35.10, -30.33) |
| 12:64875737 | V>I | A:310 | (92.49, 44.01, -23.31) | |
| 12:64875753 | rs369620088 | S>L | A:315 | (86.55, 49.46, -9.50) |
| 12:64875770 | rs371915560 | A>T | A:321 | (90.19, 44.34, -11.50) |
| 12:64875771 | A>V | A:321 | (90.19, 44.34, -11.50) | |
| 12:64875773 | rs145905497 | H>Y | A:322 | (87.67, 44.73, -13.88) |
| 12:64875774 | H>R | A:322 | (87.67, 44.73, -13.88) | |
| 12:64875792 | S>N | A:328 | (89.20, 47.70, -32.51) | |
| 12:64875797 | N>D | A:330 | (83.73, 47.87, -30.65) | |
| 12:64875801 | rs200758840 | T>I | A:331 | (81.83, 51.81, -29.52) |
| 12:64878087 | T>P | A:333 | (78.52, 52.59, -26.16) | |
| 12:64878090 | I>V | A:334 | (80.11, 48.51, -26.82) | |
| 12:64878091 | I>T | A:334 | (80.11, 48.51, -26.82) | |
| 12:64878118 | T>S | A:343 | (80.64, 46.79, -12.36) | |
| 12:64878127 | I>T | A:346 | (74.62, 52.57, -15.00) | |
| 12:64878160 | R>Q | A:357 | (93.96, 64.93, -16.47) | |
| 12:64878162 | R>C | A:358 | (87.53, 63.98, -14.89) | |
| 12:64878163 | rs374208742 | R>H | A:358 | (87.53, 63.98, -14.89) |
| 12:64878181 | G>E | A:364 | (82.12, 56.62, -31.03) | |
| 12:64878185 | R>S | A:365 | (87.26, 57.23, -28.43) | |
| 12:64878195 | H>N | A:369 | (91.20, 55.30, -31.68) | |
| 12:64878225 | I>V | A:379 | (90.79, 53.17, -17.23) | |
| 12:64878231 | V>I | A:381 | (85.52, 53.23, -12.61) | |
| 12:64878240 | R>W | A:384 | (78.51, 61.24, -8.21) | |
| 12:64878241 | rs138369490 | R>Q | A:384 | (78.51, 61.24, -8.21) |
| 12:64878243 | E>K | A:385 | (75.16, 56.04, -6.79) | |
| 12:64878246 | P>A | A:386 | (76.12, 53.57, -3.71) | |
| 12:64878252 | rs17857028 | N>D | A:388 | (79.08, 46.74, -2.10) |
| 12:64878265 | L>S | A:392 | (90.69, 39.52, -4.47) | |
| 12:64878269 | I>M | A:393 | (87.02, 36.94, -4.73) | |
| 12:64878276 | K>E | A:396 | (90.67, 30.69, 1.40) | |
| 12:64879243 | rs547073707 | P>S | A:400 | (98.77, 19.34, 1.94) |
| 12:64879246 | K>E | A:401 | (98.41, 16.90, 6.19) | |
| 12:64879256 | P>Q | A:404 | (105.28, 10.15, 7.03) | |
| 12:64879259 | R>H | A:405 | (105.36, 4.86, 3.58) | |
| 12:64879709 | rs138839127 | I>V | A:418 | (103.06, 21.70, -0.81) |
| 12:64879721 | V>M | A:422 | (103.00, 28.22, -1.87) | |
| 12:64879776 | R>Q | A:440 | (97.87, 52.88, -2.08) | |
| 12:64879788 | R>Q | A:444 | (97.40, 59.57, -5.50) | |
| 12:64882295 | T>A | A:457 | (82.65, 75.87, -7.74) | |
| 12:64882317 | rs35635889 | V>A | A:464 | (78.45, 85.36, -9.19) |
| 12:64882319 | V>L | A:465 | (79.86, 87.67, -5.77) | |
| 12:64882330 | L>F | A:468 | (75.11, 89.85, -6.58) | |
| 12:64882352 | E>K | A:476 | (71.67, 102.62, -3.07) | |
| 12:64882355 | K>E | A:477 | (74.33, 104.78, -8.65) | |
| 12:64882358 | T>P | A:478 | (70.08, 105.16, -9.03) | |
| 12:64882359 | T>I | A:478 | (70.08, 105.16, -9.03) | |
| 12:64883834 | M>V | A:486 | (57.35, 105.33, -4.63) | |
| 12:64883886 | T>I | A:503 | (63.98, 91.81, -0.18) | |
| 12:64889263 | rs144424516 | L>I | A:508 | (70.48, 85.88, -3.19) |
| 12:64889273 | S>F | A:511 | (72.19, 82.17, 0.06) | |
| 12:64889279 | G>E | A:513 | (76.90, 82.42, 2.97) | |
| 12:64889285 | rs151225287 | I>T | A:515 | (77.48, 78.57, -0.27) |
| 12:64889308 | rs139195702 | D>N | A:523 | (88.88, 73.19, 1.93) |
| 12:64889344 | rs199905735 COSM35729 COSM1363613 |
A>T | A:535 | (97.24, 58.87, 5.39) |
| 12:64889354 | rs375428983 | H>R | A:538 | (100.07, 56.33, 2.70) |
| 12:64889372 | P>L | A:544 | (106.22, 47.65, -2.29) | |
| 12:64889381 | R>K | A:547 | (111.15, 42.89, -0.80) | |
| 12:64889494 | Q>H | A:553 | (109.46, 33.49, -4.88) | |
| 12:64889526 | Y>C | A:564 | (112.02, 20.61, -10.27) | |
| 12:64889544 | K>R | A:570 | (109.65, 9.23, -9.66) | |
| 12:64889547 | A>V | A:571 | (113.33, 8.30, -12.00) | |
| 12:64889552 | R>C | A:573 | (112.81, 3.52, -9.76) | |
| 12:64889553 | rs186475789 | R>H | A:573 | (112.81, 3.52, -9.76) |
| 12:64890177 | rs375610142 | K>R | A:584 | (113.75, 12.36, 4.44) |
| 12:64890182 | D>N | A:586 | (114.75, 17.90, 2.11) | |
| 12:64890764 | T>M | A:599 | (102.20, 32.10, 8.50) | |
| 12:64890787 | K>E | A:607 | (95.76, 40.82, 9.49) | |
| 12:64890823 | W>R | A:619 | (88.13, 57.82, 1.04) | |
| 12:64890945 | rs199605037 | K>R | A:622 | (83.88, 59.81, 4.33) |
| 12:64890954 | H>R | A:625 | (78.39, 63.08, 2.22) | |
| 12:64890967 | Q>H | A:629 | (77.75, 67.92, 0.58) | |
| 12:64890972 | L>S | A:631 | (76.75, 68.53, -7.07) | |
| 12:64890974 | S>T | A:632 | (74.46, 71.03, -4.00) | |
| 12:64890984 | rs376688012 | N>S | A:635 | (73.74, 72.93, -8.71) |
| 12:64890995 | D>H | A:639 | (70.33, 78.25, -9.28) | |
| 12:64891008 | E>V | A:643 | (67.65, 84.51, -9.97) | |
| 12:64891017 | K>R | A:646 | (66.53, 88.08, -13.93) | |
| 12:64891037 | rs144370662 | E>Q | A:653 | (63.58, 102.31, -16.91) |
| 12:64891431 | rs187122554 | Q>E | A:655 | (64.44, 106.53, -21.12) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 12:64849723 | COSM942503 | R>C | A:25 | (118.24, 14.99, -27.65) |
| 12:64858120 | COSM1559401 | T>P | A:79 | (117.36, -1.45, -39.67) |
| 12:64858210 | COSM1559403 | E>K | A:109 | (94.74, 35.57, -18.98) |
| 12:64868086 | COSM1677151 | S>I | A:206 | (89.82, 16.82, -26.55) |
| 12:64889344 | COSM1363613 | A>T | A:535 | (97.24, 58.87, 5.39) |
| 12:64890170 | COSM1628778 | I>F | A:582 | (119.30, 13.98, 1.99) |