General Structure Information
| PDB ID | 2wfd |
| HGNC Gene Label(s) | LARS |
| Structure Name | structure of the human cytosolic leucyl-trna synthetase editing domain |
| Resolution | 3.25Å |
| Reference | AUTH E.SEIRADAKE,W.MAO,V.HERNANDEZ,S.J.BAKER,AUTH 2 J.J.PLATTNER,M.R.K.ALLEY,S.CUSACKTITL CRYSTAL STRUCTURES OF THE HUMAN AND FUNGALTITL 2 CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAINS:TITL 3 A STRUCTURAL BASIS FOR THE RATIONAL DESIGN OFTITL 4 ANTIFUNGAL BENZOXABOROLES.REF J.MOL.BIOL. V. 390 196 2009REFN ISSN 0022-2836PMID 19426743DOI 10.1016/J.JMB.2009.04.073 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 241 |
| Number Of SNVs | 54 |
| Number Of Permutations | 5459 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.014 |
| p-value | 0.768 |
COSMIC
| Number Of Residues | 241 |
| Number Of SNVs | 5 |
| Number Of Permutations | 451 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.2 |
| p-value | 0.462 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.292 |
| p-value | 0.665 |