General Structure Information
| PDB ID | 4fnw |
| HGNC Gene Label(s) | ALK |
| Structure Name | crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain |
| Resolution | 1.75Å |
| Reference | AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 304 |
| Number Of SNVs | 74 |
| Number Of Permutations | 33324 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.192 |
| p-value | 0.129 |
ClinVar
| Number Of Residues | 304 |
| Number Of SNVs | 8 |
| Number Of Permutations | 3346 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.429 |
| p-value | 0.039 |
COSMIC
| Number Of Residues | 304 |
| Number Of SNVs | 16 |
| Number Of Permutations | 3101 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.35 |
| p-value | 0.013 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 74 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.285 |
| p-value | 0.016 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 74 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.121 |
| p-value | 0.078 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
