General Structure Information
| PDB ID | 4i2x |
| HGNC Gene Label(s) | SIRPG |
| Structure Name | crystal structure of signal regulatory protein gamma (sirp-gamma) in complex with fabox117 |
| Resolution | 2.48Å |
| Reference | AUTH J.E.NETTLESHIP,J.REN,D.J.SCOTT,N.RAHMAN,D.HATHERLEY,Y.ZHAO,AUTH 2 D.I.STUART,A.N.BARCLAY,R.J.OWENSTITL CRYSTAL STRUCTURE OF SIGNAL REGULATORY PROTEIN GAMMA (SIRPTITL 2 GAMMA) IN COMPLEX WITH AN ANTIBODY FAB FRAGMENT.REF BMC STRUCT.BIOL. V. 13 13 2013REFN ESSN 1472-6807PMID 23826770DOI 10.1186/1472-6807-13-13 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 296 |
| Number Of SNVs | 95 |
| Number Of Permutations | 26166 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.026 |
| p-value | 1.0 |
COSMIC
| Number Of Residues | 296 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1820 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.167 |
| p-value | 0.669 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 95 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | -0.491 |
| p-value | 0.605 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
