General Structure Information
| PDB ID | 2k40 |
| HGNC Gene Label(s) | HESX1 |
| Structure Name | nmr structure of hesx-1 homeodomain double mutant r31l/e42l |
| Resolution | -1.0Å |
| Reference | AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 67 |
| Number Of SNVs | 17 |
| Number Of Permutations | 2006 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.199 |
| p-value | 0.106 |
ClinVar
| Number Of Residues | 67 |
| Number Of SNVs | 3 |
| Number Of Permutations | 101 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.0 |
| p-value | 0.486 |
COSMIC
| Number Of Residues | 67 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.333 |
| p-value | 0.596 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 17 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.199 |
| p-value | 0.828 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 17 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.252 |
| p-value | 0.676 |