General Structure Information
| PDB ID | 3kjd |
| HGNC Gene Label(s) | PARP2 |
| Structure Name | human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 |
| Resolution | 1.95Å |
| Reference | AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 341 |
| Number Of SNVs | 98 |
| Number Of Permutations | 44971 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.058 |
| p-value | 0.15 |
COSMIC
| Number Of Residues | 341 |
| Number Of SNVs | 9 |
| Number Of Permutations | 2975 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.028 |
| p-value | 0.366 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 98 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.031 |
| p-value | 0.765 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
