General Structure Information
| PDB ID | 1y8r |
| HGNC Gene Label(s) | UBA2 |
| Structure Name | sumo e1 activating enzyme sae1-sae2-sumo1-mg-atp complex |
| Resolution | 2.75Å |
| Reference | AUTH L.M.LOIS,C.D.LIMATITL STRUCTURES OF THE SUMO E1 PROVIDE MECHANISTICTITL 2 INSIGHTS INTO SUMO ACTIVATION AND E2 RECRUITMENTTITL 3 TO E1REF EMBO J. V. 24 439 2005REFN ISSN 0261-4189PMID 15660128DOI 10.1038/SJ.EMBOJ.7600552 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 514 |
| Number Of SNVs | 69 |
| Number Of Permutations | 45090 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.207 |
| p-value | 0.181 |
COSMIC
| Number Of Residues | 514 |
| Number Of SNVs | 3 |
| Number Of Permutations | 193 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.333 |
| p-value | 0.455 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 69 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.271 |
| p-value | 0.724 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
