General Structure Information
| PDB ID | 2rjq |
| HGNC Gene Label(s) | ADAMTS5 |
| Structure Name | crystal structure of adamts5 with inhibitor bound |
| Resolution | 2.6Å |
| Reference | AUTH L.MOSYAK,K.GEORGIADIS,T.SHANE,K.SVENSON,T.HEBERT,T.MCDONAGH,AUTH 2 S.MACKIE,S.OLLAND,L.LIN,X.ZHONG,R.KRIZ,E.L.REIFENBERG,AUTH 3 L.A.COLLINS-RACIE,C.CORCORAN,B.FREEMAN,R.ZOLLNER,T.MARVELL,AUTH 4 M.VERA,P.E.SUM,E.R.LAVALLIE,M.STAHL,W.SOMERSTITL CRYSTAL STRUCTURES OF THE TWO MAJOR AGGRECAN DEGRADINGTITL 2 ENZYMES, ADAMTS4 AND ADAMTS5.REF PROTEIN SCI. V. 17 16 2008REFN ISSN 0961-8368PMID 18042673DOI 10.1110/PS.073287008 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 292 |
| Number Of SNVs | 61 |
| Number Of Permutations | 11105 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.047 |
| p-value | 0.78 |
COSMIC
| Number Of Residues | 292 |
| Number Of SNVs | 10 |
| Number Of Permutations | 7843 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.044 |
| p-value | 0.254 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 61 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.176 |
| p-value | 0.114 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
