General Structure Information
| PDB ID | 2x7f |
| HGNC Gene Label(s) | TNIK |
| Structure Name | crystal structure of the kinase domain of human traf2- and nck-interacting kinase with wee1chk1 inhibitor |
| Resolution | 2.8Å |
| Reference | AUTH M.VOLLMAR,I.ALFANO,B.SHRESTHA,J.BRAY,J.R.C.MUNIZ,A.ROOS,AUTH 2 P.FILIPPAKOPOULOS,N.BURGESS-BROWN,E.UGOCHUKWU,O.GILEADI,AUTH 3 C.PHILLIPS,P.MAHAJAN,A.C.W.PIKE,O.FEDOROV,A.CHAIKUAD,AUTH 4 F.VON DELFT,C.BOUNTRA,C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,AUTH 5 S.KNAPPTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF HUMAN TRAF2- ANDTITL 2 NCK-INTERACTING KINASE WITH WEE1CHK1 INHIBITORREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 285 |
| Number Of SNVs | 27 |
| Number Of Permutations | 4606 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.009 |
| p-value | 0.813 |
COSMIC
| Number Of Residues | 285 |
| Number Of SNVs | 3 |
| Number Of Permutations | 361 |
| Optimal Distance Threshold | 49.0 |
| K Statistic | 0.333 |
| p-value | 0.01 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.376 |
| p-value | 0.193 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
