4AE4.B | UBAP1

PDB ID	4ae4
HGNC Gene Label(s)	UBAP1
Structure Name	the ubap1 subunit of escrt-i interacts with ubiquitin via a novel souba domain
Resolution	1.65Å
Reference	AUTH M.AGROMAYOR,N.SOLER,A.CABALLE,T.KUECK,S.M.FREUND,M.D.ALLEN,AUTH 2 M.BYCROFT,O.PERISIC,Y.YE,B.MCDONALD,H.SCHEEL,K.HOFMANN,AUTH 3 S.J.D.NEIL,J.MARTIN-SERRANO,R.L.WILLIAMSTITL THE UBAP1 SUBUNIT OF ESCRT-I INTERACTS WITH UBIQUITIN VIA ATITL 2 SOUBA DOMAIN.REF STRUCTURE V. 20 414 2012REFN ISSN 0969-2126PMID 22405001DOI 10.1016/J.STR.2011.12.013

ExAC Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:34249859		S>F	B:389	(34.84, -31.82, 53.13)
9:34249861		P>S	B:390	(33.21, -33.65, 55.64)
9:34249864		S>R	B:391	(30.15, -32.40, 53.18)
9:34249867		E>K	B:392	(33.26, -32.06, 49.70)
9:34249870		R>W	B:393	(34.10, -37.14, 52.71)
9:34249871	COSM608680	R>Q	B:393	(34.10, -37.14, 52.71)
9:34249882	rs138812386	E>K	B:397	(29.46, -42.04, 49.66)
9:34249886	rs139312253	T>M	B:398	(25.25, -40.21, 47.78)
9:34249907		S>L	B:405	(31.21, -41.15, 37.54)
9:34249912		E>K	B:407	(35.42, -37.62, 35.89)
9:34249913		E>A	B:407	(35.42, -37.62, 35.89)
9:34249945	rs146620671	E>K	B:418	(28.27, -29.51, 48.45)
9:34249952		I>S	B:420	(23.15, -34.25, 47.03)
9:34250656		I>V	B:423	(25.49, -32.42, 42.45)
9:34250657		I>N	B:423	(25.49, -32.42, 42.45)
9:34250662	COSM3930029 COSM3930028	D>N	B:425	(20.06, -30.13, 38.65)
9:34250671		F>I	B:428	(18.94, -34.61, 34.25)
9:34250704	COSM1108418 COSM1598228	D>N	B:439	(29.18, -27.44, 22.86)
9:34250737		H>Y	B:450	(21.63, -17.98, 33.56)
9:34250743		C>R	B:452	(18.04, -18.94, 38.80)
9:34250744		C>Y	B:452	(18.04, -18.94, 38.80)
9:34250752		E>K	B:455	(13.02, -18.99, 30.29)
9:34251418	rs148277146	K>T	B:466	(23.11, -17.38, 16.52)
9:34251426		E>Q	B:469	(27.48, -21.28, 15.19)
9:34251450		I>V	B:477	(29.21, -14.04, 23.14)
9:34251471		H>Y	B:484	(22.55, -6.10, 26.46)
9:34251474	rs556099212	N>D	B:485	(18.74, -9.73, 30.00)
9:34251478		N>S	B:486	(19.75, -12.78, 26.94)
9:34251480		D>N	B:487	(18.39, -8.37, 23.51)
9:34251513		R>W	B:498	(33.31, -6.09, 20.29)
9:34251520	rs537789793	G>E	B:500	(37.45, -6.68, 14.14)

4AE4.B | UBAP1.