General Structure Information
| PDB ID | 3l46 |
| HGNC Gene Label(s) | ECT2 |
| Structure Name | crystal structure of the second brct domain of epithelial cell transforming 2 (ect2) |
| Resolution | 1.48Å |
| Reference | AUTH L.NEDYALKOVA,W.TEMPEL,Y.TONG,L.CROMBET,H.WANG,X.GUAN,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,AUTH 3 H.PARKTITL CRYSTAL STRUCTURE OF THE SECOND BRCT DOMAIN OF EPITHELIALTITL 2 CELL TRANSFORMING 2 (ECT2)REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 94 |
| Number Of SNVs | 23 |
| Number Of Permutations | 3593 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.051 |
| p-value | 0.234 |
COSMIC
| Number Of Residues | 94 |
| Number Of SNVs | 3 |
| Number Of Permutations | 46 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.333 |
| p-value | 0.838 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 23 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.314 |
| p-value | 0.357 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
