General Structure Information
| PDB ID | 3ote |
| HGNC Gene Label(s) | THG1L |
| Structure Name | crystal structure of human trnahis guanylyltransferase (thg1)- native i |
| Resolution | 2.56Å |
| Reference | AUTH S.J.HYDE,B.E.ECKENROTH,B.A.SMITH,W.A.EBERLEY,N.H.HEINTZ,AUTH 2 J.E.JACKMAN,S.DOUBLIETITL TRNAHIS GUANYLYLTRANSFERASE (THG1), A UNIQUE 3-5TITL 2 NUCLEOTIDYL TRANSFERASE, SHARES UNEXPECTED STRUCTURALTITL 3 HOMOLOGY WITH CANONICAL 5-3 DNA POLYMERASES.REF PROC.NATL.ACAD.SCI.USA V. 107 20305 2010REFN ISSN 0027-8424PMID 21059936DOI 10.1073/PNAS.1010436107 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 240 |
| Number Of SNVs | 65 |
| Number Of Permutations | 49521 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.56 |
| p-value | 0.176 |
COSMIC
| Number Of Residues | 240 |
| Number Of SNVs | 3 |
| Number Of Permutations | 326 |
| Optimal Distance Threshold | 52.0 |
| K Statistic | 0.667 |
| p-value | 0.118 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 65 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 38.0 |
| K Statistic | -0.531 |
| p-value | 0.046 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
