3GLS.A | SIRT3

General Structure Information

PDB ID	3gls
HGNC Gene Label(s)	SIRT3
Structure Name	crystal structure of human sirt3
Resolution	2.7Å
Reference	AUTH L.JIN,W.WEI,Y.JIANG,H.PENG,J.CAI,C.MAO,H.DAI,AUTH 2 W.CHOY,J.E.BEMIS,M.R.JIROUSEK,J.C.MILNE,AUTH 3 C.H.WESTPHAL,R.B.PERNITITL CRYSTAL STRUCTURES OF HUMAN SIRT3 DISPLAYINGTITL 2 SUBSTRATE-INDUCED CONFORMATIONAL CHANGES.REF J.BIOL.CHEM. V. 284 24394 2009REFN ISSN 0021-9258PMID 19535340DOI 10.1074/JBC.M109.014928

Variant Set Distributions

ExAC Variants

Number Of Residues	273
Number Of SNVs	91
Number Of Permutations	35012
Optimal Distance Threshold	16.0
K Statistic	0.2
p-value	0.401

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:233445	rs369069267	S>Y	A:124	(1.97, 6.90, -15.72)
11:233431		A>T	A:129	(5.23, 12.89, -11.23)
11:233418	rs149834775	R>Q	A:133	(5.98, 18.79, -10.96)
11:233419	rs202072152	R>W	A:133	(5.98, 18.79, -10.96)
11:233407		C>R	A:137	(2.07, 14.00, -2.93)
11:233401		R>G	A:139	(0.50, 12.66, 3.55)
11:233397		V>G	A:140	(5.45, 9.68, 0.76)
11:233394		V>A	A:141	(5.10, 5.70, 2.43)
11:233395		V>L	A:141	(5.10, 5.70, 2.43)
11:233392		V>I	A:142	(9.04, 4.40, 1.20)
11:233387	rs199655982	M>I	A:143	(8.10, -0.25, 1.28)
11:233380	rs147810576	A>S	A:146	(18.08, -5.21, -1.40)
11:233364	rs140359001	P>R	A:151	(24.02, -0.59, -6.11)
11:233359		G>S	A:153	(28.09, -3.25, -2.83)
11:233353		P>T	A:155	(27.70, -7.73, 0.38)
11:233350		D>N	A:156	(24.30, -11.76, -0.10)
11:233345		F>L	A:157	(24.22, -13.50, 4.33)
11:233344		R>G	A:158	(21.31, -15.45, 2.29)
11:233213		S>L	A:159	(25.54, -15.07, -1.83)
11:233211		P>S	A:160	(27.69, -17.63, -3.30)
11:233201		G>D	A:163	(33.90, -12.41, 0.98)
11:233180	rs554747177	Q>R	A:170	(36.21, -19.55, 8.89)
11:233175		D>N	A:172	(30.64, -25.19, 12.62)
11:233168	rs200996811	P>L	A:174	(24.72, -25.19, 9.50)
11:233154		I>V	A:179	(24.52, -15.51, 11.49)
11:233145		L>F	A:182	(19.57, -16.35, 19.67)
11:233130		H>Y	A:187	(28.14, -22.09, 20.26)
11:233120	rs199531458	K>R	A:190	(33.42, -14.84, 17.08)
11:233109		T>A	A:194	(32.14, -11.28, 10.79)
11:233088		P>T	A:201	(28.75, 2.11, 9.99)
11:233079	rs145984757	Y>H	A:204	(29.82, -0.58, 2.14)
11:233067	rs11246020	V>I	A:208	(20.87, 7.58, -6.46)
11:233052	rs200303594	L>I	A:213	(14.73, 8.47, -0.32)
11:233048		R>Q	A:214	(18.54, 13.83, 1.89)
11:233049	rs1734492	R>G	A:214	(18.54, 13.83, 1.89)
11:233024	rs200084876	L>P	A:222	(9.22, 11.31, 3.76)
11:233018		R>Q	A:224	(7.50, 7.34, 8.52)
11:233019	rs202208408	R>W	A:224	(7.50, 7.34, 8.52)
11:233013	rs546753768	Y>H	A:226	(8.11, 1.62, 6.97)
11:233004		N>D	A:229	(17.88, -3.01, 4.37)
11:232998		D>N	A:231	(22.77, -1.16, 5.20)
11:232985	rs200625315	R>K	A:235	(20.41, 6.21, 10.62)
11:230549	rs371590252	S>L	A:237	(21.73, 9.60, 3.38)
11:230540	rs555278374	P>L	A:240	(15.96, 11.33, 9.97)
11:230510	rs200275187	T>I	A:250	(20.12, -1.16, 13.87)
11:230493	rs377446199	C>S	A:256	(23.26, -6.14, 27.22)
11:230489		T>I	A:257	(22.64, -10.07, 26.42)
11:230477	rs201985813	R>T	A:261	(22.60, -1.53, 30.96)
11:230474	rs61748606	P>H	A:262	(21.09, 0.76, 26.51)
11:230453	rs199663456	R>Q	A:269	(33.08, 1.43, 15.22)
11:230454		R>W	A:269	(33.08, 1.43, 15.22)
11:224214		P>L	A:278	(31.51, -6.69, 22.27)
11:224211	rs142592164	R>H	A:279	(32.84, -8.25, 27.71)
11:224206		P>S	A:281	(30.17, -2.14, 31.31)
11:224203		V>I	A:282	(27.73, -3.17, 34.39)
11:224199		C>F	A:283	(27.85, -7.33, 33.37)
11:224196		T>I	A:284	(30.87, -8.36, 31.61)
11:224194	rs147722093	G>S	A:285	(28.43, -9.03, 28.64)
11:224181	rs200209873	P>H	A:289	(23.99, -5.58, 17.74)
11:224179	rs201289946	D>N	A:290	(19.69, -3.54, 18.30)
11:224157	rs201905714	P>L	A:297	(10.28, -9.62, 18.29)
11:224136		L>P	A:304	(4.55, 3.72, 13.37)
11:224114		M>I	A:311	(-1.74, 9.49, 6.87)
11:224079		E>A	A:323	(9.12, -13.16, -0.45)
11:219035		P>A	A:326	(4.79, -8.68, 8.12)
11:219028		A>V	A:328	(4.28, -7.48, 2.18)
11:219026		S>G	A:329	(0.78, -7.06, 3.94)
11:219010		V>A	A:334	(-2.62, 1.69, 1.06)
11:219011	rs147582800	V>M	A:334	(-2.62, 1.69, 1.06)
11:219007		R>Q	A:335	(-6.19, 5.73, 1.41)
11:219008	rs202066094	R>W	A:335	(-6.19, 5.73, 1.41)
11:219002		S>A	A:337	(-7.22, 6.48, -3.40)
11:218999	rs200944124	V>L	A:338	(-3.36, 5.61, -2.73)
11:218992		R>Q	A:340	(-0.09, 0.26, -4.85)
11:218990	rs374879005	L>M	A:341	(5.42, 3.29, -7.64)
11:218984		I>V	A:343	(10.86, 1.14, -8.66)
11:218980		N>S	A:344	(11.63, -4.01, -8.72)
11:218978	rs201115579	R>W	A:345	(14.87, -6.17, -12.48)
11:218974	COSM1746181	D>G	A:346	(10.18, -8.31, -10.93)
11:218975	rs185287384	D>N	A:346	(10.18, -8.31, -10.93)
11:218972		L>M	A:347	(5.16, -7.57, -10.75)
11:218947		P>L	A:355	(-4.04, -5.97, -8.89)
11:218945		R>C	A:356	(-4.93, -1.80, -5.50)
11:218942	rs149887273	S>R	A:357	(-6.36, 0.94, -10.49)
11:218933		V>M	A:360	(2.65, 2.19, -11.37)
11:218930	rs139026266	A>T	A:361	(5.29, -0.48, -12.78)
11:218921		G>R	A:364	(13.88, -2.69, -13.64)
11:218918		D>N	A:365	(17.84, -0.91, -12.96)
11:218911		V>A	A:367	(19.33, 3.19, -10.51)
11:218906	rs3020901	G>S	A:369	(14.08, 4.30, -12.62)
11:218903	rs146003473	V>M	A:370	(15.09, 6.33, -9.69)
11:218891		V>M	A:374	(14.48, 12.49, -11.03)
11:218885		L>F	A:376	(9.34, 12.50, -15.15)
11:218881		L>P	A:377	(9.88, 14.92, -10.53)
11:218861	rs201069150	R>W	A:384	(23.34, 15.54, -11.38)
11:218851		V>G	A:387	(25.29, 13.10, -5.13)
11:218848	rs111450242	Q>R	A:388	(28.19, 16.26, -6.11)
11:218845	rs200203977	R>Q	A:389	(26.64, 19.13, -2.02)
11:218846		R>W	A:389	(26.64, 19.13, -2.02)
11:218832	rs139644721	K>N	A:393	(30.44, 15.30, 3.47)