General Structure Information
| PDB ID | 3rau |
| HGNC Gene Label(s) | PTPN23 |
| Structure Name | crystal structure of the hd-ptp bro1 domain |
| Resolution | 1.95Å |
| Reference | AUTH P.SETTE,R.MU,V.DUSSUPT,J.JIANG,G.SNYDER,P.SMITH,T.S.XIAO,AUTH 2 F.BOUAMRTITL THE PHE105 LOOP OF ALIX BRO1 DOMAIN PLAYS A KEY ROLE INTITL 2 HIV-1 RELEASE.REF STRUCTURE V. 19 1485 2011REFN ISSN 0969-2126PMID 21889351DOI 10.1016/J.STR.2011.07.016 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 357 |
| Number Of SNVs | 80 |
| Number Of Permutations | 64957 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.158 |
| p-value | 0.328 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:47422621 | L>Q | B:12 | (-15.76, 36.46, 10.05) | |
| 3:47422651 | F>Y | B:22 | (-14.47, 23.93, -14.63) | |
| 3:47437649 | Y>C | B:34 | (-8.34, 10.48, -20.49) | |
| 3:47437654 | E>K | B:36 | (-11.95, 9.87, -24.14) | |
| 3:47437656 | E>D | B:36 | (-11.95, 9.87, -24.14) | |
| 3:47437670 | Y>C | B:41 | (-16.43, 12.96, -19.26) | |
| 3:47437673 | N>S | B:42 | (-20.70, 17.61, -20.80) | |
| 3:47446152 | rs374121377 | R>H | B:57 | (-24.51, 33.92, -4.89) |
| 3:47446154 | V>F | B:58 | (-24.29, 30.22, 0.52) | |
| 3:47446166 | F>V | B:62 | (-26.40, 23.36, 9.45) | |
| 3:47446184 | L>V | B:68 | (-19.58, 25.26, 1.44) | |
| 3:47446188 | rs367969329 | R>H | B:69 | (-18.59, 20.92, 4.93) |
| 3:47446196 | L>F | B:72 | (-14.18, 21.49, -0.48) | |
| 3:47446200 | G>A | B:73 | (-14.79, 17.74, -2.26) | |
| 3:47446209 | H>R | B:76 | (-10.21, 17.89, -2.80) | |
| 3:47446239 | rs149197378 | S>L | B:86 | (0.58, 25.43, -9.43) |
| 3:47446266 | T>I | B:95 | (-10.87, 35.11, -9.32) | |
| 3:47446548 | Q>L | B:114 | (-9.61, 23.86, -2.54) | |
| 3:47446563 | rs567056020 | Y>C | B:119 | (-12.21, 32.65, 4.86) |
| 3:47447242 | rs548310469 | A>V | B:123 | (-17.45, 32.47, 8.07) |
| 3:47447260 | G>A | B:129 | (-22.97, 31.48, 16.27) | |
| 3:47447277 | V>M | B:135 | (-31.73, 31.31, 25.81) | |
| 3:47447414 | rs147034860 | V>F | B:142 | (-25.19, 24.85, 18.54) |
| 3:47447438 | COSM1642285 | A>T | B:150 | (-14.50, 28.07, 12.62) |
| 3:47447444 | G>S | B:152 | (-10.95, 24.64, 11.93) | |
| 3:47447453 | A>T | B:155 | (-6.59, 25.87, 11.11) | |
| 3:47447462 | R>W | B:158 | (-2.86, 28.00, 10.88) | |
| 3:47447463 | rs188888990 | R>Q | B:158 | (-2.86, 28.00, 10.88) |
| 3:47447468 | rs555640873 | H>Y | B:160 | (-3.03, 22.03, 5.18) |
| 3:47447473 | rs138320436 | F>L | B:161 | (-3.26, 26.28, 2.28) |
| 3:47447475 | P>L | B:162 | (1.82, 27.76, 4.45) | |
| 3:47447489 | rs377445101 | V>I | B:167 | (-3.61, 39.37, 3.09) |
| 3:47447501 | R>C | B:171 | (0.72, 31.13, 9.95) | |
| 3:47447514 | T>M | B:175 | (-3.83, 32.89, 14.51) | |
| 3:47447517 | L>P | B:176 | (-6.95, 36.77, 15.05) | |
| 3:47447522 | V>I | B:178 | (-8.31, 30.43, 15.69) | |
| 3:47447528 | L>F | B:180 | (-12.00, 35.40, 18.12) | |
| 3:47447830 | C>R | B:188 | (-20.57, 29.37, 25.02) | |
| 3:47447849 | M>T | B:194 | (-22.88, 29.45, 34.77) | |
| 3:47447867 | S>N | B:200 | (-17.18, 27.54, 41.74) | |
| 3:47447875 | V>M | B:203 | (-16.78, 28.34, 36.62) | |
| 3:47447881 | R>C | B:205 | (-9.60, 26.13, 35.61) | |
| 3:47447884 | rs139402667 | I>V | B:206 | (-14.22, 27.69, 32.29) |
| 3:47447890 | A>T | B:208 | (-9.58, 32.04, 32.58) | |
| 3:47447988 | K>N | B:215 | (-4.90, 37.87, 27.03) | |
| 3:47447998 | rs372446033 | R>W | B:219 | (-1.18, 39.05, 22.85) |
| 3:47448016 | rs367996199 | D>N | B:225 | (1.19, 44.66, 10.27) |
| 3:47448023 | rs369118542 | A>V | B:227 | (-4.18, 47.54, 11.78) |
| 3:47448026 | S>L | B:228 | (-3.04, 48.22, 8.35) | |
| 3:47448037 | rs556275635 | R>W | B:232 | (-12.71, 51.68, 12.49) |
| 3:47448040 | I>L | B:233 | (-12.59, 45.94, 11.66) | |
| 3:47448049 | D>N | B:236 | (-14.97, 46.74, 16.55) | |
| 3:47448080 | Y>C | B:246 | (-9.79, 43.71, 32.13) | |
| 3:47448082 | Y>H | B:247 | (-17.40, 40.18, 32.04) | |
| 3:47448085 | F>L | B:248 | (-15.20, 36.80, 30.80) | |
| 3:47448094 | rs202048605 | V>M | B:251 | (-16.39, 35.98, 36.14) |
| 3:47448101 | H>P | B:253 | (-10.95, 36.68, 40.53) | |
| 3:47448102 | rs139838618 | H>Q | B:253 | (-10.95, 36.68, 40.53) |
| 3:47448199 | M>V | B:256 | (-11.85, 31.76, 43.06) | |
| 3:47448214 | rs147122610 | E>K | B:261 | (-18.65, 31.65, 50.41) |
| 3:47448226 | rs142355354 | K>Q | B:265 | (-10.89, 30.28, 53.03) |
| 3:47448229 | rs549990673 | F>L | B:266 | (-15.11, 33.76, 55.62) |
| 3:47448230 | F>Y | B:266 | (-15.11, 33.76, 55.62) | |
| 3:47448232 | rs146048311 | G>R | B:267 | (-10.78, 36.79, 53.51) |
| 3:47448239 | rs148327878 | R>Q | B:269 | (-16.17, 35.85, 50.97) |
| 3:47448626 | Y>N | B:272 | (-10.30, 35.84, 45.11) | |
| 3:47448644 | rs375689982 | D>N | B:278 | (-11.14, 46.35, 40.86) |
| 3:47448654 | N>S | B:281 | (-14.88, 48.95, 37.53) | |
| 3:47448657 | E>V | B:282 | (-10.84, 48.52, 33.38) | |
| 3:47448666 | K>R | B:285 | (-12.98, 52.56, 31.81) | |
| 3:47448805 | P>S | B:291 | (-23.96, 48.17, 22.74) | |
| 3:47448814 | V>M | B:294 | (-22.51, 45.29, 26.65) | |
| 3:47448823 | COSM4118049 | A>T | B:297 | (-24.15, 42.74, 31.26) |
| 3:47448824 | rs146035301 | A>V | B:297 | (-24.15, 42.74, 31.26) |
| 3:47448829 | R>C | B:299 | (-25.99, 48.48, 34.55) | |
| 3:47448830 | rs201653035 COSM1045575 |
R>H | B:299 | (-25.99, 48.48, 34.55) |
| 3:47448838 | M>V | B:302 | (-21.94, 46.23, 39.19) | |
| 3:47448848 | I>T | B:305 | (-19.64, 41.40, 41.84) | |
| 3:47448854 | G>E | B:307 | (-23.15, 42.28, 46.81) | |
| 3:47449008 | K>E | B:313 | (-16.05, 44.03, 53.89) | |
| 3:47449017 | N>D | B:316 | (-14.46, 39.85, 57.70) | |
| 3:47449020 | COSM1222545 | D>N | B:317 | (-15.62, 43.94, 58.92) |
| 3:47449041 | V>I | B:324 | (-7.58, 40.60, 53.53) | |
| 3:47449042 | V>A | B:324 | (-7.58, 40.60, 53.53) | |
| 3:47449068 | V>I | B:333 | (-6.95, 31.14, 37.79) | |
| 3:47449204 | rs370594347 | P>T | B:341 | (-9.73, 23.35, 16.69) |
| 3:47449259 | K>R | B:359 | (-17.41, 8.03, -15.64) |