General Structure Information
| PDB ID | 2jfl |
| HGNC Gene Label(s) | SLK |
| Structure Name | crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide |
| Resolution | 2.2Å |
| Reference | AUTH A.C.W.PIKE,P.RELLOS,F.H.NIESEN,A.TURNBULL,A.W.OLIVER,AUTH 2 S.A.PARKER,B.E.TURK,L.H.PEARL,S.KNAPPTITL ACTIVATION SEGMENT DIMERIZATION: A MECHANISM FOR KINASETITL 2 AUTOPHOSPHORYLATION OF NON-CONSENSUS SITES.REF EMBO J. V. 27 704 2008REFN ISSN 0261-4189PMID 18239682DOI 10.1038/EMBOJ.2008.8 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 286 |
| Number Of SNVs | 37 |
| Number Of Permutations | 22486 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.032 |
| p-value | 0.536 |