4G1C.B | SIRT5

General Structure Information

PDB ID	4g1c
HGNC Gene Label(s)	SIRT5
Structure Name	human sirt5 bound to succ-idh2 and carba-nad
Resolution	1.94Å
Reference	AUTH B.G.SZCZEPANKIEWICZ,H.DAI,K.J.KOPPETSCH,D.QIAN,F.JIANG,AUTH 2 C.MAO,R.B.PERNITITL SYNTHESIS OF CARBA-NAD AND THE STRUCTURES OF ITS TERNARYTITL 2 COMPLEXES WITH SIRT3 AND SIRT5.REF J.ORG.CHEM. V. 77 7319 2012REFN ISSN 0022-3263PMID 22849721DOI 10.1021/JO301067E

Variant Set Distributions

ExAC Variants

Number Of Residues	267
Number Of SNVs	84
Number Of Permutations	38420
Optimal Distance Threshold	13.0
K Statistic	0.141
p-value	0.681

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
6:13588578	COSM258012 COSM258013	R>Q	B:44	(0.63, 49.19, 27.60)
6:13588646	rs142986214	V>L	B:67	(1.34, 26.16, 10.68)
6:13588649		P>S	B:68	(2.38, 22.64, 10.40)
6:13588650	COSM3410607 COSM3410608	P>L	B:68	(2.38, 22.64, 10.40)
6:13588653		T>N	B:69	(5.07, 22.58, 14.08)
6:13588658	rs201440696	R>G	B:71	(9.19, 17.05, 18.16)
6:13588668		G>V	B:74	(2.90, 15.93, 15.86)
6:13588674	rs199972179	Y>C	B:76	(5.65, 12.12, 13.98)
6:13588695		Q>R	B:83	(14.09, 17.14, 14.34)
6:13591901		D>H	B:84	(14.98, 13.19, 11.41)
6:13591902	rs151080671	D>G	B:84	(14.98, 13.19, 11.41)
6:13591908	rs141049222	A>V	B:86	(16.08, 19.00, 9.21)
6:13591913		P>S	B:88	(22.41, 17.71, 6.82)
6:13591935	rs202061819 COSM233369 COSM233370	P>L	B:95	(17.20, 14.33, -2.17)
6:13591938	rs372975181	S>F	B:96	(13.21, 13.18, -3.00)
6:13591940	rs201184922	R>W	B:97	(12.48, 10.80, 2.03)
6:13591941	rs202209176	R>Q	B:97	(12.48, 10.80, 2.03)
6:13591950		E>V	B:100	(8.19, 14.58, -1.00)
6:13591954	rs201979175	F>L	B:101	(9.15, 17.78, 4.83)
6:13591958		H>Y	B:103	(5.75, 20.30, -2.21)
6:13591965	rs200525112	R>Q	B:105	(6.88, 22.45, 5.59)
6:13591967	rs201187185	R>W	B:106	(6.69, 25.51, -0.89)
6:13591983	rs532065496	S>N	B:111	(-4.18, 27.88, 3.46)
6:13591986	rs375984507	K>T	B:112	(-2.47, 28.41, 6.50)
6:13591990	rs145299575	E>D	B:113	(-3.45, 33.69, 6.23)
6:13591991	rs199661343	P>T	B:114	(-1.74, 35.93, 9.30)
6:13591998	rs35745768	A>D	B:116	(-3.58, 38.23, 15.93)
6:13592000	rs146470521	G>R	B:117	(-0.27, 38.22, 16.51)
6:13592006		R>C	B:119	(-3.27, 40.48, 12.63)
6:13592007	COSM1073638 COSM1073639	R>H	B:119	(-3.27, 40.48, 12.63)
6:13592016		A>V	B:122	(2.89, 44.60, 12.44)
6:13592020	rs567756394	E>D	B:123	(-0.80, 46.37, 13.69)
6:13592030	rs199938759	R>W	B:127	(1.39, 51.99, 16.15)
6:13592031	rs200846116	R>Q	B:127	(1.39, 51.99, 16.15)
6:13592033	rs201987782	L>V	B:128	(6.07, 52.51, 17.28)
6:13592048	rs200208625	R>W	B:133	(8.56, 54.09, 19.39)
6:13592052		R>Q	B:134	(14.16, 49.96, 15.06)
6:13592057	rs138633880	V>M	B:136	(12.95, 44.39, 15.18)
6:13592078	rs201247677	D>N	B:143	(6.17, 30.56, 8.00)
6:13592081		E>K	B:144	(7.49, 34.05, 4.74)
6:13592090	rs139920526	R>C	B:147	(7.35, 38.73, 3.83)
6:13592091	rs200249177 COSM1440677 COSM1440678	R>H	B:147	(7.35, 38.73, 3.83)
6:13592124	rs143612733	H>R	B:158	(16.33, 29.37, 11.35)
6:13595744	rs199854042	V>I	B:171	(22.42, 31.37, -6.05)
6:13595747	rs188775956	V>M	B:172	(19.83, 32.74, -2.89)
6:13595750	rs148020996	A>T	B:173	(16.15, 32.42, -4.68)
6:13595753		E>K	B:174	(12.26, 35.04, -3.85)
6:13595757		N>S	B:175	(10.56, 29.70, -5.30)
6:13595765	rs145972102	S>R	B:178	(2.64, 25.83, -7.22)
6:13595775		C>F	B:181	(8.68, 20.68, -9.55)
6:13595777	rs201704328	P>S	B:182	(6.83, 19.20, -12.35)
6:13595784	rs200388975	L>S	B:184	(7.00, 17.61, -6.32)
6:13595795		G>S	B:188	(3.82, 14.91, 0.07)
6:13597233		V>A	B:201	(18.33, 14.14, -8.89)
6:13597235		E>K	B:202	(17.86, 16.30, -13.36)
6:13597237		E>D	B:202	(17.86, 16.30, -13.36)
6:13597245		P>L	B:205	(14.46, 21.40, -7.90)
6:13597248	COSM3393826 COSM3393827	R>Q	B:206	(18.37, 21.08, -10.98)
6:13599268	rs199558608	E>K	B:208	(16.75, 28.28, -14.00)
6:13599275		A>V	B:210	(23.67, 30.76, -15.91)
6:13599280		C>R	B:212	(23.88, 25.90, -13.43)
6:13599287		G>D	B:214	(21.90, 22.53, -10.22)
6:13599299		P>R	B:218	(15.84, 23.99, 0.79)
6:13599328	rs35730049	D>Y	B:228	(24.05, 34.02, 7.87)
6:13599331	rs201467255	P>S	B:229	(27.26, 35.01, 9.59)
6:13599334	rs199917917	A>T	B:230	(25.38, 38.46, 8.65)
6:13599346		E>K	B:234	(21.52, 42.22, 11.35)
6:13599350		V>A	B:235	(20.74, 39.56, 15.88)
6:13599352	rs202074148	D>N	B:236	(24.26, 40.31, 17.88)
6:13599360	COSM1162657 COSM1162658	E>D	B:238	(18.81, 44.88, 16.90)
6:13599364		A>T	B:240	(22.60, 45.32, 22.38)
6:13599371	rs200377799	C>Y	B:242	(17.26, 46.69, 23.21)
6:13599377		L>S	B:244	(11.49, 46.15, 25.49)
6:13599382	rs201991505	L>V	B:246	(8.75, 41.08, 23.24)
6:13599385		V>L	B:247	(9.86, 36.09, 23.99)
6:13601066	rs150051127	V>L	B:248	(6.64, 35.13, 21.23)
6:13601072	rs145409640	T>A	B:250	(9.83, 30.54, 22.49)
6:13601075		S>A	B:251	(9.25, 26.32, 23.91)
6:13601106	rs373453442	A>V	B:261	(16.26, 36.65, 25.94)
6:13601112	rs140128318	Q>P	B:263	(22.30, 37.85, 27.15)
6:13601115	rs201526536	V>A	B:264	(18.28, 40.94, 27.02)
6:13601124		R>M	B:267	(21.70, 44.26, 28.56)
6:13601129	rs146449652	V>M	B:269	(16.71, 44.76, 29.53)
6:13601144		F>L	B:274	(3.99, 37.33, 25.41)
6:13601151	COSM98217	T>M	B:276	(1.30, 28.14, 26.47)
6:13601169	rs143092270	T>M	B:282	(10.40, 32.30, 32.87)
6:13601179	rs9464003	F>L	B:285	(12.24, 36.39, 31.34)
6:13612026	COSM1754543	H>Y	B:288	(4.87, 34.69, 31.89)
6:13612027		H>R	B:288	(4.87, 34.69, 31.89)
6:13612041		C>R	B:293	(-0.03, 34.67, 21.59)
6:13612048	rs550780850	T>M	B:295	(-5.25, 36.47, 23.26)
6:13612065		L>V	B:301	(1.22, 45.28, 21.15)