General Structure Information
| PDB ID | 4cek |
| HGNC Gene Label(s) | UPF2 |
| Structure Name | crystal structure of the second mif4g domain of human nonsense mediated decay factor upf2 |
| Resolution | 2.35Å |
| Reference | AUTH M.CLERICI,A.DENIAUD,V.BOEHM,N.H.GEHRING,C.SCHAFFITZEL,AUTH 2 S.CUSACKTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE THREE MIF4GTITL 2 DOMAINS OF NONSENSE-MEDIATED DECAY FACTOR UPF2.REF NUCLEIC ACIDS RES. V. 42 2673 2014REFN ISSN 0305-1048PMID 24271394DOI 10.1093/NAR/GKT1197 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 240 |
| Number Of SNVs | 33 |
| Number Of Permutations | 20616 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.35 |
| p-value | 0.473 |
COSMIC
| Number Of Residues | 240 |
| Number Of SNVs | 4 |
| Number Of Permutations | 113 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.5 |
| p-value | 0.079 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 33 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.246 |
| p-value | 0.378 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
