General Structure Information
| PDB ID | 2y43 |
| HGNC Gene Label(s) | RAD18 |
| Structure Name | rad18 ubiquitin ligase ring domain structure |
| Resolution | 1.8Å |
| Reference | AUTH A.HUANG,R.G.HIBBERT,R.N.DE JONG,D.DAS,T.K.SIXMA,R.BOELENSTITL SYMMETRY AND ASYMMETRY OF THE RING-RING DIMER OF RAD18.REF J.MOL.BIOL. V. 410 424 2011REFN ISSN 0022-2836PMID 21549715DOI 10.1016/J.JMB.2011.04.051 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 89 |
| Number Of SNVs | 31 |
| Number Of Permutations | 3623 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.086 |
| p-value | 0.792 |
COSMIC
| Number Of Residues | 89 |
| Number Of SNVs | 3 |
| Number Of Permutations | 237 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.667 |
| p-value | 0.841 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.29 |
| p-value | 0.757 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
