General Structure Information
| PDB ID | 2vhf |
| HGNC Gene Label(s) | CYLD |
| Structure Name | structure of the cyld usp domain |
| Resolution | 2.8Å |
| Reference | AUTH D.KOMANDER,C.J.LORD,H.SCHEEL,S.SWIFT,K.HOFMANN,AUTH 2 A.ASHWORTH,D.BARFORDTITL THE STRUCTURE OF THE CYLD USP DOMAIN EXPLAINS ITSTITL 2 SPECIFICITY FOR LYS63-LINKED POLYUBIQUITIN ANDTITL 3 REVEALS A B-BOX MODULEREF MOL.CELL.BIOL. V. 29 451 2008REFN ISSN 0270-7306PMID 18313383DOI 10.1016/J.MOLCEL.2007.12.018 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 334 |
| Number Of SNVs | 37 |
| Number Of Permutations | 22064 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.036 |
| p-value | 0.394 |
COSMIC
| Number Of Residues | 334 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 37 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.509 |
| p-value | 0.432 |