2FP0.B | ADPRHL2

General Structure Information

PDB ID	2fp0
HGNC Gene Label(s)	ADPRHL2
Structure Name	human adp-ribosylhydrolase 3
Resolution	2.05Å
Reference	AUTH C.MUELLER-DIECKMANN,S.KERNSTOCK,M.LISUREK,J.P.VON KRIES,AUTH 2 F.HAAG,M.S.WEISS,F.KOCH-NOLTETITL THE STRUCTURE OF HUMAN ADP-RIBOSYLHYDROLASE 3 (ARH3)TITL 2 PROVIDES INSIGHTS INTO THE REVERSIBILITY OF PROTEINTITL 3 ADP-RIBOSYLATION.REF PROC.NATL.ACAD.SCI.USA V. 103 15026 2006REFN ISSN 0027-8424PMID 17015823DOI 10.1073/PNAS.0606762103

Variant Set Distributions

ExAC Variants

Number Of Residues	337
Number Of SNVs	89
Number Of Permutations	12329
Optimal Distance Threshold	10.0
K Statistic	0.052
p-value	0.247

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
1:36554636	rs546261317	D>G	B:28	(43.75, -16.60, 57.85)
1:36554644		D>N	B:31	(41.46, -11.71, 66.05)
1:36554684		P>R	B:44	(50.14, 6.05, 75.23)
1:36554686		D>N	B:45	(51.19, 9.62, 77.63)
1:36556852		L>F	B:57	(53.13, 1.97, 60.37)
1:36556863		D>G	B:61	(50.62, -0.70, 46.83)
1:36556895		S>P	B:72	(50.20, 13.96, 37.90)
1:36556908		K>R	B:76	(50.54, 18.43, 33.94)
1:36556912		E>D	B:77	(47.29, 22.40, 36.60)
1:36556914		A>D	B:78	(45.44, 17.79, 34.99)
1:36556931		M>V	B:84	(49.45, 9.46, 35.75)
1:36556934	rs144958655	A>T	B:85	(52.25, 6.60, 33.49)
1:36557233		Y>C	B:92	(58.54, -0.50, 40.02)
1:36557236	rs181905364	K>R	B:93	(62.86, 2.40, 37.98)
1:36557237		K>N	B:93	(62.86, 2.40, 37.98)
1:36557239	rs368622368	K>T	B:94	(61.99, 5.15, 43.92)
1:36557240	rs372904964	K>N	B:94	(61.99, 5.15, 43.92)
1:36557252		R>S	B:98	(56.62, 0.60, 49.33)
1:36557275		T>N	B:106	(53.84, -6.61, 34.01)
1:36557301		K>Q	B:115	(60.03, 0.27, 21.63)
1:36557308	rs371118290	R>H	B:117	(55.12, 5.50, 20.67)
1:36557322		P>A	B:122	(50.30, -2.22, 28.47)
1:36557328	COSM3985012	R>W	B:124	(43.14, -3.94, 26.93)
1:36557329	rs555751880	R>Q	B:124	(43.14, -3.94, 26.93)
1:36557332		A>V	B:125	(47.31, -7.03, 27.15)
1:36557343	COSM1185408	G>R	B:129	(42.65, -8.70, 26.55)
1:36557356		Y>C	B:133	(39.08, -8.95, 37.61)
1:36557373	rs149598595	M>V	B:139	(44.59, 1.47, 45.34)
1:36557377	rs199607845	R>Q	B:140	(45.29, 4.24, 41.64)
1:36557379		V>L	B:141	(40.93, 7.10, 42.66)
1:36557385		G>S	B:143	(42.29, 12.39, 43.83)
1:36557388	rs543843820	I>L	B:144	(40.43, 11.93, 40.50)
1:36557391	rs142886947	S>P	B:145	(37.50, 13.32, 43.64)
1:36557401	rs139736291	Y>C	B:148	(38.84, 16.58, 38.02)
1:36557403		S>G	B:149	(34.03, 18.99, 40.95)
1:36557413	rs149705523	Q>R	B:152	(29.91, 13.59, 34.40)
1:36557517		R>W	B:159	(36.41, 5.56, 32.85)
1:36557518	rs374286043	R>Q	B:159	(36.41, 5.56, 32.85)
1:36557529		Q>E	B:163	(41.68, 2.55, 31.42)
1:36557535	rs141355724	T>A	B:165	(46.61, -0.58, 35.48)
1:36557548	COSM3489006	S>F	B:169	(34.90, -3.14, 33.15)
1:36557553		G>R	B:171	(37.92, -2.43, 37.31)
1:36557559		N>D	B:173	(33.23, 0.26, 36.62)
1:36557560		N>S	B:173	(33.23, 0.26, 36.62)
1:36557565	rs372664717	A>T	B:175	(37.29, 3.14, 40.34)
1:36557577	rs146885889	A>S	B:179	(35.39, 8.13, 43.09)
1:36557584		A>G	B:181	(32.26, 7.84, 47.15)
1:36557589		H>Y	B:183	(31.77, 13.46, 44.50)
1:36557605		G>V	B:188	(28.54, 15.42, 53.61)
1:36557619	rs2236387	E>K	B:193	(18.32, 5.55, 52.74)
1:36557623		H>R	B:194	(20.84, 10.61, 49.30)
1:36557641		L>P	B:200	(22.25, 2.55, 42.38)
1:36557644	rs146990907	G>D	B:201	(22.57, 5.40, 39.50)
1:36557649	rs372964784	M>V	B:203	(27.15, 2.18, 38.72)
1:36557670		A>T	B:210	(28.57, -2.93, 26.15)
1:36557671		A>V	B:210	(28.57, -2.93, 26.15)
1:36557674		Q>P	B:211	(32.93, -3.56, 27.26)
1:36557677		S>Y	B:212	(30.23, -3.59, 31.07)
1:36557679	rs189656035	V>I	B:213	(27.40, -6.34, 29.51)
1:36557693		R>S	B:217	(27.40, -11.91, 28.78)
1:36558031		M>T	B:221	(29.48, -11.93, 36.83)
1:36558039	rs201025691	R>C	B:224	(23.27, -3.95, 35.83)
1:36558040	rs148612837	R>H	B:224	(23.27, -3.95, 35.83)
1:36558043		P>R	B:225	(27.94, -6.29, 38.95)
1:36558048		S>P	B:227	(24.30, -2.46, 40.64)
1:36558055	COSM1667408	R>H	B:229	(27.88, -6.71, 44.21)
1:36558067		I>T	B:233	(25.05, -2.56, 50.64)
1:36558093		V>L	B:242	(25.11, -8.27, 59.94)
1:36558704		G>D	B:254	(38.97, -9.13, 47.83)
1:36558722		S>L	B:260	(36.63, -4.46, 47.46)
1:36558751		R>C	B:270	(28.05, -1.41, 60.18)
1:36558759		M>I	B:272	(27.46, 6.41, 59.48)
1:36558761	rs527784721	E>V	B:273	(25.32, 4.44, 63.41)
1:36558763	rs372701793	P>S	B:274	(27.02, 2.87, 66.88)
1:36558764	rs375995036	P>L	B:274	(27.02, 2.87, 66.88)
1:36558769		P>S	B:276	(28.59, -2.82, 70.57)
1:36558791	rs373961966	N>S	B:283	(36.01, 8.25, 65.92)
1:36558797		L>P	B:285	(37.44, 7.71, 60.99)
1:36558826	rs146218730	L>V	B:295	(35.95, -7.88, 57.24)
1:36558830		G>D	B:296	(39.71, -9.39, 56.09)
1:36558838		T>A	B:299	(43.08, -5.53, 55.01)
1:36558848	rs549427499	I>T	B:302	(38.99, -2.91, 52.03)
1:36558854		T>I	B:304	(42.64, 2.68, 51.70)
1:36558856		M>V	B:305	(38.98, 1.94, 49.58)
1:36558857	rs144031883	M>T	B:305	(38.98, 1.94, 49.58)
1:36558890		M>T	B:316	(41.75, 15.92, 60.07)
1:36558899	rs201735454	V>G	B:319	(42.32, 12.25, 62.07)
1:36558902	rs200099878	P>L	B:320	(43.70, 10.84, 65.38)
1:36558929		G>A	B:329	(54.31, 10.30, 55.56)
1:36558931		Y>H	B:330	(52.85, 12.56, 59.29)
1:36558934	rs550523074	E>K	B:331	(54.93, 15.42, 57.54)
1:36558941		T>I	B:333	(50.03, 13.18, 52.98)
1:36558956	rs571967173	Q>R	B:338	(47.97, 21.78, 52.09)
1:36558958		S>G	B:339	(48.64, 21.25, 47.14)
1:36558965		H>P	B:341	(42.33, 23.39, 48.75)
1:36558967	rs560312697	R>C	B:342	(47.58, 25.59, 46.14)
1:36558980	rs375689539	K>R	B:346	(41.76, 28.30, 47.22)
1:36558984		S>R	B:347	(39.02, 28.38, 42.36)