General Structure Information
| PDB ID | 4edj |
| HGNC Gene Label(s) | GORASP2 |
| Structure Name | crystal structure of the grasp55 grasp domain with a phosphomimetic mutation (s189d) |
| Resolution | 1.9Å |
| Reference | AUTH S.T.TRUSCHEL,M.ZHANG,C.BACHERT,M.R.MACBETH,A.D.LINSTEDTTITL ALLOSTERIC REGULATION OF GRASP PROTEIN-DEPENDENT GOLGITITL 2 MEMBRANE TETHERING BY MITOTIC PHOSPHORYLATION.REF J.BIOL.CHEM. V. 287 19870 2012REFN ISSN 0021-9258PMID 22523075DOI 10.1074/JBC.M111.326256 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 203 |
| Number Of SNVs | 30 |
| Number Of Permutations | 4280 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.17 |
| p-value | 0.075 |
COSMIC
| Number Of Residues | 203 |
| Number Of SNVs | 6 |
| Number Of Permutations | 2297 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.267 |
| p-value | 0.272 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 30 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.205 |
| p-value | 0.665 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
