2V4U.A | CTPS2

PDB ID	2v4u
HGNC Gene Label(s)	CTPS2
Structure Name	human ctp synthetase 2 – glutaminase domain in complex with 5-oxo-l-norleucine
Resolution	2.3Å
Reference	AUTH M.WELIN,M.MOCHE,J.ANDERSSON,C.H.ARROWSMITH,AUTH 2 H.BERGLUND,R.COLLINS,L.G.DAHLGREN,A.M.EDWARDS,AUTH 3 S.FLODIN,A.FLORES,S.GRASLUND,M.HAMMARSTROM,AUTH 4 A.JOHANSSON,I.JOHANSSON,T.KARLBERG,T.KOTENYOVA,AUTH 5 L.LEHTIO,M.E.NILSSON,T.NYMAN,K.OLESEN,C.PERSSON,AUTH 6 J.SAGEMARK,H.SCHUELER,A.G.THORSELL,L.TRESAUGUES,AUTH 7 S.VAN DEN BERG,M.WISNIEWSKA,J.WEIGELT,M.WIKSTROM,AUTH 8 P.NORDLUNDTITL HUMAN CTP SYNTHETASE 2 – GLUTAMINASE DOMAIN INTITL 2 COMPLEX WITH 5-OXO-L-NORLEUCINEREF TO BE PUBLISHEDREFN

ExAC Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
X:16701279	rs148995160	A>T	A:315	(-39.74, 15.08, -2.65)
X:16701249	rs370911868	A>S	A:325	(-34.19, 17.13, -16.61)
X:16701240		I>V	A:328	(-31.13, 16.47, -20.39)
X:16701233		H>R	A:330	(-35.58, 17.32, -21.81)
X:16701219		M>V	A:335	(-46.99, 10.27, -15.31)
X:16696554	rs374430696	L>P	A:342	(-52.13, -0.95, -12.97)
X:16696540		E>K	A:347	(-60.63, -4.21, -15.27)
X:16696536	rs138897680	T>I	A:348	(-63.97, -5.31, -11.83)
X:16696537		T>A	A:348	(-63.97, -5.31, -11.83)
X:16696492		K>Q	A:363	(-47.79, 8.45, -22.05)
X:16688784		P>S	A:370	(-40.50, 4.00, -5.86)
X:16688743	rs369198202	Q>H	A:383	(-48.83, -5.69, -13.67)
X:16688741		A>V	A:384	(-45.07, -2.28, -14.30)
X:16685817		I>T	A:407	(-39.74, -11.27, -7.41)
X:16685668		T>I	A:422	(-40.57, -13.35, 3.67)
X:16657335		N>T	A:443	(-25.19, -3.13, 18.36)
X:16657333		L>V	A:444	(-28.24, -6.20, 21.64)
X:16657319		M>I	A:448	(-32.54, -1.53, 9.51)
X:16657290	rs146570387	K>R	A:458	(-19.76, -7.83, -8.78)
X:16638435	rs372927744	P>S	A:472	(-14.52, 1.15, -7.40)
X:16638430	rs367685844	F>L	A:473	(-16.03, 2.84, -3.83)
X:16635334		N>K	A:495	(-30.35, -15.91, -17.22)
X:16635332		D>G	A:496	(-30.30, -11.55, -19.29)
X:16635312		D>N	A:503	(-22.11, -5.80, 0.72)
X:16635309	COSM1118513	V>I	A:504	(-18.03, -4.72, 1.77)
X:16627754	rs189978215	M>T	A:534	(-24.72, 21.14, -10.70)
X:16627743		P>A	A:538	(-26.31, 8.82, -11.24)
X:16627689		Q>E	A:556	(-19.58, 8.83, -26.94)

2V4U.A | CTPS2.