General Structure Information
| PDB ID | 3zqs |
| HGNC Gene Label(s) | FANCL |
| Structure Name | human fancl central domain |
| Resolution | 2.0Å |
| Reference | AUTH C.HODSON,A.R.COLE,L.P.LEWIS,J.A.MILES,AUTH 2 A.PURKISS-TREW,H.WALDENTITL STRUCTURAL ANALYSIS OF HUMAN FANCL, THE E3 LIGASETITL 2 IN THE FANCONI ANEMIA PATHWAY.REF J.BIOL.CHEM. V. 286 32628 2011REFN ISSN 0021-9258PMID 21775430DOI 10.1074/JBC.M111.244632 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 186 |
| Number Of SNVs | 60 |
| Number Of Permutations | 36986 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.124 |
| p-value | 0.851 |
COSMIC
| Number Of Residues | 186 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2157 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.2 |
| p-value | 0.81 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 31.0 |
| K Statistic | 0.228 |
| p-value | 0.692 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
