General Structure Information
| PDB ID | 4b6l |
| HGNC Gene Label(s) | PLK3 |
| Structure Name | discovery of oral polo-like kinase (plk) inhibitors with enhanced selectivity profile using residue targeted drug design |
| Resolution | 1.9Å |
| Reference | AUTH K.BROWN,J.D.CHARRIER,S.DURRANT,M.GRIFFITHS,C.HUDSON,D.KAY,AUTH 2 R.KNEGTEL,M.ODONNELL,F.PIERARD,H.TWIN,P.WEBER,S.YOUNGTITL DISCOVERY OF ORAL POLO-LIKE KINASE (PLK) INHIBITORS WITHTITL 2 ENHANCED SELECTIVITY PROFILE USING RESIDUE TARGETED DRUGTITL 3 DESIGNREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 281 |
| Number Of SNVs | 73 |
| Number Of Permutations | 34565 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.056 |
| p-value | 0.46 |