General Structure Information
| PDB ID | 3w3g |
| HGNC Gene Label(s) | TLR8 |
| Structure Name | crystal structure of human tlr8 (unliganded form) |
| Resolution | 2.3Å |
| Reference | AUTH H.TANJI,U.OHTO,T.SHIBATA,K.MIYAKE,T.SHIMIZUTITL STRUCTURAL REORGANIZATION OF THE TOLL-LIKE RECEPTOR 8 DIMERTITL 2 INDUCED BY AGONISTIC LIGANDSREF SCIENCE V. 339 1426 2013REFN ISSN 0036-8075PMID 23520111DOI 10.1126/SCIENCE.1229159 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 752 |
| Number Of SNVs | 80 |
| Number Of Permutations | 13836 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.041 |
| p-value | 0.322 |
COSMIC
| Number Of Residues | 752 |
| Number Of SNVs | 12 |
| Number Of Permutations | 4275 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.015 |
| p-value | 0.731 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 80 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | -0.037 |
| p-value | 0.852 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
