2WM3.A | NMRAL1

General Structure Information

PDB ID	2wm3
HGNC Gene Label(s)	NMRAL1
Structure Name	crystal structure of nmra-like family domain containing protein 1 in complex with niflumic acid
Resolution	1.85Å
Reference	AUTH C.BHATIA,W.W.YUE,E.PILKA,E.UGOCHUKWU,P.SAVITSKY,V.HOZJAN,AUTH 2 A.K.ROOS,P.FILIPPAKOPOULOS,F.VON DELFT,T.HEIGHTMAN,AUTH 3 C.ARROWSMITH,J.WEIGELT,A.EDWARDS,C.BOUNTRA,U.OPPERMANNTITL CRYSTAL STRUCTURE OF NMRA-LIKE FAMILY DOMAIN CONTAININGTITL 2 PROTEIN 1 IN COMPLEX WITH NIFLUMIC ACIDREF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	296
Number Of SNVs	120
Number Of Permutations	15866
Optimal Distance Threshold	14.0
K Statistic	0.141
p-value	0.595

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
16:4524124		K>E	A:4	(39.05, 28.75, 80.46)
16:4524108		V>G	A:9	(50.79, 21.02, 85.19)
16:4524109		V>L	A:9	(50.79, 21.02, 85.19)
16:4524103	rs149317402	G>R	A:11	(55.57, 19.71, 88.62)
16:4524096	rs142221148	T>I	A:13	(55.83, 21.52, 93.38)
16:4524097		T>P	A:13	(55.83, 21.52, 93.38)
16:4519457		G>A	A:17	(56.05, 23.31, 86.52)
16:4519454		G>D	A:18	(56.06, 26.02, 88.02)
16:4519449	rs77934295	V>M	A:20	(54.38, 25.98, 83.31)
16:4519442	rs150925122	R>H	A:22	(54.51, 30.05, 88.58)
16:4519443	rs141993533	R>C	A:22	(54.51, 30.05, 88.58)
16:4519439	rs11557236	T>I	A:23	(53.13, 31.33, 82.91)
16:4519415	rs373098518	K>T	A:31	(42.88, 26.04, 83.02)
16:4519409	COSM178937	R>Q	A:33	(43.81, 19.62, 86.71)
16:4519407		V>M	A:34	(48.64, 21.01, 89.74)
16:4519397	rs143521179	R>Q	A:37	(54.18, 12.98, 95.36)
16:4519388	rs151062838	R>T	A:40	(49.59, 20.00, 102.06)
16:4519389		R>G	A:40	(49.59, 20.00, 102.06)
16:4519382	rs148847461	K>T	A:42	(53.83, 25.54, 100.44)
16:4519379	rs370838589	A>V	A:43	(53.89, 24.95, 96.72)
16:4519368	COSM291223	L>V	A:47	(49.97, 26.93, 92.74)
16:4519356	rs148537261	G>C	A:51	(44.12, 29.24, 90.63)
16:4519346		V>A	A:54	(45.62, 21.12, 93.49)
16:4519343	rs376569795	V>A	A:55	(45.20, 17.15, 92.12)
16:4519322	rs555219424	Q>R	A:62	(46.96, 3.31, 85.18)
16:4519319		V>G	A:63	(43.71, 4.74, 88.23)
16:4519311		E>Q	A:66	(42.32, 7.78, 83.70)
16:4519305		A>T	A:68	(44.12, 13.73, 86.22)
16:4519301		L>R	A:69	(44.76, 13.40, 82.25)
16:4519286		A>V	A:74	(46.55, 19.56, 77.60)
16:4519287		A>T	A:74	(46.55, 19.56, 77.60)
16:4519275	rs140164470	V>M	A:78	(57.84, 16.58, 84.21)
16:4519268	rs146163636	N>I	A:80	(62.49, 13.52, 88.91)
16:4519261	rs369860675	W>C	A:82	(68.35, 12.85, 89.40)
16:4519260		E>K	A:83	(62.33, 10.87, 93.49)
16:4519249		S>R	A:86	(64.87, 4.65, 87.88)
16:4519250		S>T	A:86	(64.87, 4.65, 87.88)
16:4519244		E>G	A:88	(63.25, 0.45, 84.67)
16:4519245		E>K	A:88	(63.25, 0.45, 84.67)
16:4519239	rs553535524	E>K	A:90	(61.74, 8.51, 83.85)
16:4516402		G>E	A:94	(55.66, 7.93, 80.37)
16:4516391	rs538518387	A>T	A:98	(51.14, 8.14, 76.62)
16:4516384		L>P	A:100	(46.35, 7.69, 79.68)
16:4516376		R>C	A:103	(42.59, 5.23, 76.81)
16:4516373		L>V	A:104	(41.92, 9.90, 77.27)
16:4516361		Y>H	A:108	(49.94, 19.66, 72.40)
16:4516355	rs150742411	V>L	A:110	(54.36, 19.51, 76.30)
16:4516351	rs374971730	Y>C	A:111	(58.11, 14.47, 77.58)
16:4516346	rs558451515	G>S	A:113	(62.87, 15.74, 77.17)
16:4516342		L>R	A:114	(66.34, 14.55, 77.20)
16:4516340		E>K	A:115	(68.71, 13.77, 73.64)
16:4516333		I>T	A:117	(72.66, 9.49, 74.47)
16:4516334	COSM4060796	I>V	A:117	(72.66, 9.49, 74.47)
16:4516321		T>M	A:121	(75.84, 6.50, 70.58)
16:4516319		A>T	A:122	(75.45, 2.74, 69.19)
16:4516316		G>R	A:123	(75.84, 2.14, 72.83)
16:4516304		A>T	A:127	(72.55, 8.52, 80.10)
16:4516301	rs148220267	A>T	A:128	(69.85, 7.48, 82.53)
16:4516296		H>Q	A:129	(70.07, 11.71, 82.92)
16:4516288		G>V	A:132	(64.37, 7.45, 78.96)
16:4516285		K>R	A:133	(63.70, 11.53, 79.47)
16:4516261		R>Q	A:141	(56.28, 11.20, 68.66)
16:4516262	rs375433527 COSM1377932	R>W	A:141	(56.28, 11.20, 68.66)
16:4516255	rs370842993	I>T	A:143	(51.26, 5.48, 70.55)
16:4516250	rs138190658	V>I	A:145	(50.43, 11.29, 70.98)
16:4516244	COSM4060795	M>V	A:147	(54.73, 15.20, 71.50)
16:4516241		T>A	A:148	(56.13, 18.99, 71.52)
16:4516235		V>M	A:150	(60.74, 20.50, 75.71)
16:4516231	rs571839313	R>Q	A:151	(65.28, 17.73, 73.56)
16:4516232		R>W	A:151	(65.28, 17.73, 73.56)
16:4516214	COSM162944	E>Q	A:157	(69.17, 27.65, 88.06)
16:4516209	rs376934274	N>K	A:158	(72.67, 23.72, 88.13)
16:4516198		H>L	A:162	(74.23, 20.33, 91.24)
16:4516196	rs114557561	F>I	A:163	(77.72, 22.49, 88.41)
16:4516190		P>A	A:165	(81.76, 27.70, 92.76)
16:4516187	rs141325916	Q>K	A:166	(84.11, 25.06, 95.53)
16:4516180	rs145544406	A>G	A:168	(90.95, 27.32, 96.08)
16:4516178		P>A	A:169	(93.78, 25.64, 97.14)
16:4516172		G>R	A:171	(91.83, 31.26, 98.92)
16:4516168	rs151279129	K>R	A:172	(92.05, 33.81, 96.38)
16:4516165		S>T	A:173	(90.06, 31.62, 94.19)
16:4513845		P>L	A:179	(82.90, 19.21, 82.22)
16:4513834	rs372774300	V>I	A:183	(82.72, 22.60, 73.37)
16:4513817		M>I	A:188	(67.59, 27.75, 80.13)
16:4513809	rs368484670	S>C	A:191	(62.36, 30.40, 85.28)
16:4513797		P>R	A:195	(56.87, 31.28, 78.60)
16:4513789		L>I	A:198	(51.91, 29.61, 76.88)
16:4513782		L>H	A:200	(54.19, 25.27, 72.33)
16:4513763		K>N	A:206	(53.55, 24.39, 64.29)
16:4513759	COSM4060794	V>I	A:208	(53.16, 18.24, 66.28)
16:4513756	rs375960349	G>S	A:209	(56.86, 16.24, 66.34)
16:4513740		L>P	A:214	(65.26, 24.76, 74.89)
16:4513734		T>I	A:216	(69.60, 31.42, 75.84)
16:4513735		T>A	A:216	(69.60, 31.42, 75.84)
16:4513726		H>Y	A:219	(78.65, 30.41, 77.16)
16:4513722	rs201897065	T>M	A:220	(83.01, 27.78, 77.57)
16:4513717		E>K	A:222	(87.37, 30.24, 79.77)
16:4513708	rs560529874	A>T	A:225	(84.15, 31.96, 84.82)
16:4513695		T>S	A:229	(84.36, 36.94, 87.90)
16:4513692		K>T	A:230	(81.17, 40.45, 85.22)
16:4513693		K>E	A:230	(81.17, 40.45, 85.22)
16:4513683	rs377584132	R>H	A:233	(81.39, 41.74, 91.51)
16:4513684	COSM1217525	R>C	A:233	(81.39, 41.74, 91.51)
16:4513681		K>E	A:234	(84.53, 36.68, 93.52)
16:4513678		V>L	A:235	(88.29, 35.33, 91.35)
16:4513675	rs375090595 COSM1217526	V>M	A:236	(85.78, 32.37, 89.12)
16:4513669		D>N	A:238	(88.23, 26.61, 84.19)
16:4511959		M>K	A:241	(86.30, 18.84, 85.11)
16:4511946		D>E	A:245	(87.34, 13.99, 86.37)
16:4511942	rs149409840	E>K	A:247	(84.12, 7.54, 84.43)
16:4511936		L>I	A:249	(83.63, 8.87, 91.28)
16:4511929		F>S	A:251	(78.58, 5.15, 93.04)
16:4511926	rs3747582	P>L	A:252	(76.25, 4.22, 89.29)
16:4511927		P>S	A:252	(76.25, 4.22, 89.29)
16:4511924		G>S	A:253	(76.38, 8.19, 87.61)
16:4511920		A>V	A:254	(79.48, 9.01, 87.25)
16:4511917	rs143394570	R>Q	A:255	(79.01, 5.02, 84.74)
16:4511918	rs147175262	R>W	A:255	(79.01, 5.02, 84.74)
16:4511914	rs137950129	D>G	A:256	(74.87, 8.46, 83.97)
16:4511912	rs368163218	L>V	A:257	(76.90, 12.93, 85.15)
16:4511896		R>H	A:262	(81.92, 11.77, 77.64)
16:4511897		R>C	A:262	(81.92, 11.77, 77.64)
16:4511893		F>Y	A:263	(75.46, 14.39, 73.80)
16:4511885		L>M	A:266	(79.44, 15.77, 70.36)
16:4511879		P>S	A:268	(73.74, 19.15, 71.35)
16:4511872		R>H	A:270	(70.03, 21.85, 72.20)
16:4511873	rs202218846	R>C	A:270	(70.03, 21.85, 72.20)
16:4511868	rs141564520	D>E	A:271	(67.04, 26.53, 68.31)
16:4511864	rs374250406	E>K	A:273	(67.21, 31.71, 66.40)
16:4511848		L>P	A:278	(58.77, 30.10, 71.82)
16:4511849	COSM327484	L>I	A:278	(58.77, 30.10, 71.82)
16:4511839	rs562879265	K>R	A:281	(61.39, 37.56, 78.17)
16:4511837	rs543114262	A>T	A:282	(64.75, 34.65, 77.84)
16:4511828		L>M	A:285	(74.69, 33.32, 81.74)
16:4511823	COSM3509643	D>E	A:286	(75.20, 38.31, 81.22)
16:4511819		W>G	A:288	(70.72, 33.63, 86.24)
16:4511809	rs143114954	Q>R	A:291	(68.20, 39.05, 87.50)
16:4511800		G>A	A:294	(73.07, 37.31, 95.34)
16:4511801	rs149095316	G>R	A:294	(73.07, 37.31, 95.34)