General Structure Information
| PDB ID | 3if8 |
| HGNC Gene Label(s) | ZWILCH |
| Structure Name | crystal structure of zwilch, a member of the rzz kinetochore complex |
| Resolution | 2.55Å |
| Reference | AUTH F.CIVRIL,A.WEHENKEL,F.M.GIORGI,S.SANTAGUIDA,A.DI FONZO,AUTH 2 G.GRIGOREAN,F.D.CICCARELLI,A.MUSACCHIOTITL STRUCTURAL ANALYSIS OF THE RZZ COMPLEX REVEALS COMMONTITL 2 ANCESTRY WITH MULTISUBUNIT VESICLE TETHERING MACHINERY.REF STRUCTURE V. 18 616 2010REFN ISSN 0969-2126PMID 20462495DOI 10.1016/J.STR.2010.02.014 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 260 |
| Number Of SNVs | 66 |
| Number Of Permutations | 64583 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.334 |
| p-value | 0.137 |
COSMIC
| Number Of Residues | 260 |
| Number Of SNVs | 4 |
| Number Of Permutations | 2100 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.167 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 66 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | -0.41 |
| p-value | 0.469 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
