General Structure Information
| PDB ID | 2gwf |
| HGNC Gene Label(s) | RNF41 |
| Structure Name | structure of a usp8-nrdp1 complex |
| Resolution | 2.3Å |
| Reference | AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 122 |
| Number Of SNVs | 15 |
| Number Of Permutations | 990 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.029 |
| p-value | 1.0 |
COSMIC
| Number Of Residues | 122 |
| Number Of SNVs | 4 |
| Number Of Permutations | 949 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | 0.833 |
| p-value | 0.429 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 15 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | -0.419 |
| p-value | 0.375 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
