General Structure Information
| PDB ID | 1jpy |
| HGNC Gene Label(s) | IL17F |
| Structure Name | crystal structure of il-17f |
| Resolution | 2.85Å |
| Reference | AUTH S.G.HYMOWITZ,E.H.FILVAROFF,J.P.YIN,J.LEE,L.CAI,P.RISSER,AUTH 2 M.MARUOKA,W.MAO,J.FOSTER,R.F.KELLEY,G.PAN,A.L.GURNEY,AUTH 3 A.M.DE VOS,M.A.STAROVASNIKTITL IL-17S ADOPT A CYSTINE KNOT FOLD: STRUCTURE AND ACTIVITY OFTITL 2 A NOVEL CYTOKINE, IL-17F, AND IMPLICATIONS FOR RECEPTORTITL 3 BINDING.REF EMBO J. V. 20 5332 2001REFN ISSN 0261-4189PMID 11574464DOI 10.1093/EMBOJ/20.19.5332 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 121 |
| Number Of SNVs | 43 |
| Number Of Permutations | 10519 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.055 |
| p-value | 0.713 |
COSMIC
| Number Of Residues | 121 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1740 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.095 |
| p-value | 0.244 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 43 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.222 |
| p-value | 0.264 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
