General Structure Information
| PDB ID | 4fmu |
| HGNC Gene Label(s) | SETD2 |
| Structure Name | crystal structure of methyltransferase domain of human set domain- containing protein 2 compound: pr-snf |
| Resolution | 2.1Å |
| Reference | AUTH W.ZHENG,G.IBANEZ,H.WU,G.BLUM,H.ZENG,A.DONG,F.LI,T.HAJIAN,AUTH 2 A.ALLALI-HASSANI,M.F.AMAYA,A.SIARHEYEVA,W.YU,P.J.BROWN,AUTH 3 M.SCHAPIRA,M.VEDADI,J.MIN,M.LUOTITL SINEFUNGIN DERIVATIVES AS INHIBITORS AND STRUCTURE PROBES OFTITL 2 PROTEIN LYSINE METHYLTRANSFERASE SETD2.REF J.AM.CHEM.SOC. V. 134 18004 2012REFN ISSN 0002-7863PMID 23043551DOI 10.1021/JA307060P |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 235 |
| Number Of SNVs | 21 |
| Number Of Permutations | 9760 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.005 |
| p-value | 0.442 |
COSMIC
| Number Of Residues | 235 |
| Number Of SNVs | 18 |
| Number Of Permutations | 11852 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.098 |
| p-value | 0.071 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.092 |
| p-value | 0.263 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
