4N1D.A | NODAL

PDB ID	4n1d
HGNC Gene Label(s)	NODAL
Structure Name	nodal/bmp2 chimera nb250
Resolution	1.91Å
Reference	AUTH L.ESQUIVIES,A.BLACKLER,M.PERAN,C.RODRIGUEZ-ESTEBAN,AUTH 2 J.C.IZPISUA BELMONTE,E.BOOKER,P.C.GRAY,C.AHN,W.KWIATKOWSKI,AUTH 3 S.CHOETITL DESIGNER NODAL/BMP2 CHIMERAS MIMIC NODAL SIGNALING, PROMOTETITL 2 CHONDROGENESIS, AND REVEAL A BMP2-LIKE STRUCTURE.REF J.BIOL.CHEM. V. 289 1788 2014REFN ISSN 0021-9258PMID 24311780DOI 10.1074/JBC.M113.529180

ExAC Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
10:72195155	rs121909283	G>R	A:27	(9.63, -34.74, -5.53)
10:72195148		G>D	A:29	(9.59, -38.77, -9.50)
10:72195140		I>L	A:32	(5.09, -40.97, -9.56)
10:72195116	COSM327485	A>T	A:40	(-5.80, -30.74, -11.78)
10:72195110		R>C	A:42	(-6.87, -23.10, -10.98)
10:72195097	rs193203393	E>A	A:46	(-15.25, -12.40, -7.16)
10:72195098	COSM32311	E>K	A:46	(-15.25, -12.40, -7.16)
10:72195086	rs375503197	P>A	A:50	(-25.39, -11.80, -2.90)
10:72195082		V>A	A:51	(-23.85, -16.11, -3.79)
10:72195069	rs150892417	F>L	A:55	(-21.34, -18.71, -8.30)
10:72195064		P>L	A:57	(-24.54, -21.71, -3.09)
10:72195065	rs370796035	P>S	A:57	(-24.54, -21.71, -3.09)
10:72192835		K>E	A:68	(-19.93, -9.34, 3.52)
10:72192831		R>H	A:69	(-24.17, -6.55, 0.26)
10:72192832	rs150819707	R>C	A:69	(-24.17, -6.55, 0.26)
10:72192820	rs148708629	H>Y	A:73	(-15.88, -3.88, 7.29)
10:72192816		R>Q	A:74	(-19.12, -9.42, 11.55)
10:72192804		T>I	A:78	(-17.76, -16.89, 0.28)

4N1D.A | NODAL.