General Structure Information
| PDB ID | 1u7t |
| HGNC Gene Label(s) | HSD17B10 |
| Structure Name | crystal structure of abad/hsd10 with a bound inhibitor |
| Resolution | 2.0Å |
| Reference | AUTH C.R.KISSINGER,P.A.REJTO,L.A.PELLETIER,J.A.THOMSON,AUTH 2 R.E.SHOWALTER,M.A.ABREO,C.S.AGREE,S.MARGOSIAK,AUTH 3 J.J.MENG,R.M.AUST,D.VANDERPOOL,B.LI,AUTH 4 A.TEMPCZYK-RUSSELL,J.E.VILLAFRANCATITL CRYSTAL STRUCTURE OF HUMAN ABAD/HSD10 WITH A BOUNDTITL 2 INHIBITOR: IMPLICATIONS FOR DESIGN OF ALZHEIMERSTITL 3 DISEASE THERAPEUTICSREF J.MOL.BIOL. V. 342 943 2004REFN ISSN 0022-2836PMID 15342248DOI 10.1016/J.JMB.2004.07.071 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 255 |
| Number Of SNVs | 18 |
| Number Of Permutations | 3429 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.026 |
| p-value | 0.703 |
ClinVar
| Number Of Residues | 255 |
| Number Of SNVs | 4 |
| Number Of Permutations | 463 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.833 |
| p-value | 0.34 |
COSMIC
| Number Of Residues | 255 |
| Number Of SNVs | 3 |
| Number Of Permutations | 106 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.333 |
| p-value | 0.457 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.314 |
| p-value | 0.158 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | -0.614 |
| p-value | 0.159 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
