3I2N.A | WDR92

General Structure Information

PDB ID	3i2n
HGNC Gene Label(s)	WDR92
Structure Name	crystal structure of wd40 repeats protein wdr92
Resolution	1.95Å
Reference	AUTH C.XU,J.MINTITL STRUCTURE AND FUNCTION OF WD40 DOMAIN PROTEINS.REF PROTEIN CELL V. 2 202 2011REFN ISSN 1674-800XPMID 21468892DOI 10.1007/S13238-011-1018-1

Variant Set Distributions

ExAC Variants

Number Of Residues	345
Number Of SNVs	84
Number Of Permutations	15384
Optimal Distance Threshold	9.0
K Statistic	0.035
p-value	0.174

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:68384559		K>R	A:6	(-31.67, 2.64, -28.13)
2:68384557	rs139978404	P>S	A:7	(-29.46, 5.64, -25.35)
2:68384551		I>V	A:9	(-25.30, 2.46, -20.65)
2:68384545		A>S	A:11	(-18.12, 1.06, -19.44)
2:68384531		K>N	A:15	(-10.30, 0.82, -9.69)
2:68384521	rs372704771	Y>H	A:19	(-13.37, -1.03, 0.19)
2:68384508	rs571851713	D>A	A:23	(-22.22, 5.90, -1.25)
2:68384505		C>S	A:24	(-20.74, 7.09, -4.66)
2:68384490		C>Y	A:29	(-16.00, 21.54, -9.31)
2:68384469	rs376341639	M>T	A:36	(-18.41, 6.01, 1.19)
2:68384462		N>K	A:38	(-16.50, -1.40, 5.41)
2:68384442		V>A	A:45	(-13.32, 3.85, 4.22)
2:68384443		V>I	A:45	(-13.32, 3.85, 4.22)
2:68384421		Q>R	A:52	(-5.49, 11.41, -13.73)
2:68384419		H>Y	A:53	(-5.06, 9.44, -18.22)
2:68384416	rs138076521	G>R	A:54	(-8.37, 8.05, -18.34)
2:68384404		L>V	A:58	(-6.10, 6.14, -4.81)
2:68374695		E>V	A:63	(-9.14, 3.94, 8.80)
2:68374683		P>L	A:67	(-18.58, 1.60, 9.34)
2:68374665	rs367839314	F>S	A:73	(-20.09, 16.70, -1.46)
2:68374633	rs151311133	A>T	A:84	(-21.38, 14.62, 4.66)
2:68374629	rs200352366	T>I	A:85	(-20.83, 11.29, 6.65)
2:68374627	rs149227337	G>R	A:86	(-23.07, 8.39, 7.73)
2:68374601		I>M	A:94	(-18.91, 17.48, 8.33)
2:68371836		A>V	A:99	(-8.04, 17.48, 6.86)
2:68371822		V>I	A:104	(-15.85, 20.31, 10.73)
2:68371813		V>I	A:107	(-23.65, 14.61, 15.93)
2:68371795	rs201071865	I>V	A:113	(-27.40, 2.84, 10.63)
2:68371792	rs569230419	I>V	A:114	(-27.07, 7.21, 9.41)
2:68371765		L>V	A:123	(-23.35, 24.61, -4.38)
2:68371725		S>T	A:136	(-32.24, 6.01, 11.01)
2:68371722	rs370123273	R>Q	A:137	(-33.04, 0.07, 12.06)
2:68371720	rs202147887	D>N	A:138	(-33.64, 5.51, 14.85)
2:68368925		T>A	A:140	(-35.50, 9.14, 13.24)
2:68368922		V>M	A:141	(-35.95, 12.01, 9.97)
2:68368915		V>A	A:143	(-32.88, 18.59, 9.76)
2:68368916		V>M	A:143	(-32.88, 18.59, 9.76)
2:68368868		V>I	A:159	(-46.07, 10.03, 18.62)
2:68368862		G>R	A:161	(-46.58, 5.83, 21.30)
2:68368837		T>S	A:169	(-34.83, 7.03, 1.97)
2:68368831	rs544805669	A>V	A:171	(-35.28, 13.63, 0.16)
2:68365986		N>S	A:174	(-40.09, 22.59, -2.61)
2:68365987		N>H	A:174	(-40.09, 22.59, -2.61)
2:68365980		Y>C	A:176	(-39.48, 27.47, -4.44)
2:68365959		V>A	A:183	(-38.15, 15.99, 3.88)
2:68365933	rs138916420	I>V	A:192	(-43.88, 7.40, 1.37)
2:68365929		K>R	A:193	(-43.84, 9.79, 5.93)
2:68365918		L>V	A:197	(-39.12, 21.77, 6.91)
2:68365911	rs376459490	N>S	A:199	(-44.36, 24.50, 8.95)
2:68365908		M>T	A:200	(-43.24, 20.75, 10.92)
2:68365909	rs368232793	M>V	A:200	(-43.24, 20.75, 10.92)
2:68365899	rs139513052	R>Q	A:203	(-47.61, 18.83, 1.87)
2:68365900	rs35021866	R>W	A:203	(-47.61, 18.83, 1.87)
2:68365890	rs141727712	T>R	A:206	(-48.15, 6.72, 1.01)
2:68365887		N>I	A:207	(-47.89, 2.23, 1.95)
2:68364528		M>T	A:224	(-42.98, 19.62, -5.47)
2:68364513		A>V	A:229	(-40.11, 5.50, -5.59)
2:68364491	rs374120850	F>L	A:236	(-40.22, 2.45, -10.86)
2:68364480		D>G	A:240	(-47.50, 14.63, -10.50)
2:68364462		P>L	A:246	(-56.66, 16.81, -0.05)
2:68364447	rs201651152	A>D	A:251	(-50.53, 10.83, -9.09)
2:68364448		A>P	A:251	(-50.53, 10.83, -9.09)
2:68364439		S>A	A:254	(-46.15, 1.59, -11.59)
2:68361927		H>R	A:258	(-37.19, -5.93, -12.43)
2:68361928		H>N	A:258	(-37.19, -5.93, -12.43)
2:68361918		T>I	A:261	(-34.04, -4.78, -5.31)
2:68361897		L>P	A:268	(-29.87, 13.98, -15.79)
2:68361888		N>S	A:271	(-33.14, 16.12, -18.13)
2:68361859	rs138784630	A>T	A:281	(-28.01, -7.51, -10.61)
2:68361856	rs369846610	G>S	A:282	(-26.55, -4.97, -12.20)
2:68361839		W>C	A:287	(-36.72, 3.84, -17.05)
2:68358575	rs141028124	E>A	A:290	(-44.32, 10.94, -20.32)
2:68358567		I>V	A:293	(-51.95, 16.40, -22.02)
2:68358560		R>Q	A:295	(-48.86, 17.55, -14.94)
2:68358552	rs147103603	K>E	A:298	(-61.46, 17.03, -11.81)
2:68358549		D>Y	A:299	(-63.11, 14.74, -8.60)
2:68358530	COSM1022328	M>T	A:305	(-57.14, 14.56, -9.07)
2:68358522	COSM194681	A>T	A:308	(-50.50, 9.87, -14.71)
2:68358515	rs148647644	S>C	A:310	(-45.48, 7.29, -19.14)
2:68358491		T>M	A:318	(-26.02, -6.29, -16.66)
2:68358488		L>S	A:319	(-22.46, -3.41, -16.00)
2:68358477		P>S	A:323	(-25.83, -5.36, -6.01)
2:68358474	rs149937589	I>V	A:324	(-25.55, -1.32, -8.91)
2:68358452		P>L	A:331	(-22.30, 17.87, -11.78)
2:68358449		D>G	A:332	(-19.27, 19.17, -13.71)
2:68358450		D>H	A:332	(-19.27, 19.17, -13.71)
2:68358443		R>K	A:334	(-24.91, 16.30, -20.89)
2:68358440		G>D	A:335	(-23.37, 11.60, -18.64)
2:68358428		C>Y	A:339	(-21.30, 3.28, -10.03)
2:68358410		T>M	A:345	(-16.37, -2.36, -8.74)
2:68358408		V>M	A:346	(-15.86, 2.01, -9.09)
2:68358393		V>I	A:351	(-24.82, 8.16, -20.93)